Annotation rule MF_01006
Send feedback

General rule information [?]

Accession MF_01006
Dates 1-MAR-2002 (Created)
28-APR-2014 (Last updated, Version 41)
Name Undec_diphosphatase
Scope Bacteria
Archaea
Templates P60932 (UPPP_ECOLI); P60934 (UPPP_STRPN): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
UPPP
case <OC:Bacteria>
Protein name
RecName: Full=Undecaprenyl-diphosphatase;
EC=3.6.1.27;
AltName: Full=Bacitracin resistance protein;
AltName: Full=Undecaprenyl pyrophosphate phosphatase;
end case
case <OC:Archaea>
Protein name
RecName: Full=Undecaprenyl-diphosphatase;
EC=3.6.1.27;
AltName: Full=Undecaprenyl pyrophosphate phosphatase;
end case
Gene name
uppP

Comments [?]

case <OC:Bacteria>
Function Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity).
end case
case <OC:Archaea>
Function Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) (By similarity).
end case
Catalytic activity Ditrans,octacis-undecaprenyl diphosphate + H(2)O = ditrans,octacis-undecaprenyl phosphate + phosphate.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein (By similarity).
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein (By similarity).
end case
case <OC:Bacteria>
Miscellaneous Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
end case
Similarity Belongs to the UppP family.

Keywords [?]

case <OC:Bacteria>
end case
case defined <Property:Membrane> and <Property:Membrane=2>
end case
case <OC:Bacteria>
end case

Gene Ontology [?]

GO:0050380; Molecular function: undecaprenyl-diphosphatase activity.
case <OC:Bacteria>
GO:0046677; Biological process: response to antibiotic.
end case
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF02673; BacA; 1;
TIGRFAMs TIGR00753; Undec_PP_bacA; 1;

Computed features [?]

General Transmembrane; -; 5-9; trigger=yes;

Additional information [?]

Size range 237-343 amino acids
Related rules None
Fusion None
Comments UPPP2 from RHILO is shorter but can not easily be extended.