HAMAP

Accession	MF_01010
Dates	25-MAR-2002 (Created) 11-NOV-2011 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_01010; [distribution of match scores in UniProtKB];[seed alignment for MF_01010]

Names

23SrRNA_methyltr_RlmD

Identifier

RLMD

Protein name

RecName: Full=23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD; EC=2.1.1.190; AltName: Full=23S rRNA(m5U1939)-methyltransferase;

Gene name

rlmD

FUNCTION: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity).

CATALYTIC ACTIVITY: S-adenosyl-L-methionine + uracil(1939) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(1939) in 23S rRNA.

SIMILARITY: Belongs to the methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.

Pfam	PF01938; TRAM; 1; PF05958; tRNA_U5-meth_tr; 1;
TIGRFAMs	TIGR00479; RumA; 1;
PROSITE	PS50926; TRAM; 0-1; trigger=PRU00208; PS01230; TRMA_1; 1; PS01231; TRMA_2; 1;

Methyltransferase, rRNA processing, S-adenosyl-L-methionine, Transferase.

4Fe-4S, Iron, Iron-sulfur, Metal-binding.

GO:0070041; Molecular function: rRNA (uridine-C5-)-methyltransferase activity.

GO:0005506; Molecular function: iron ion binding.

GO:0031167; Biological process: rRNA methylation.

From: RLMD_ECOLI (P55135)
Key		From		To		Description		Condition		FTGroup
INIT_MET		1		1		Removed (By similarity)		M

Key		From		To		Description		Condition		FTGroup
ACT_SITE		389		389		Nucleophile (By similarity)		C
METAL		81		81		Iron-sulfur (4Fe-4S) (By similarity)		C		1
METAL		87		87		Iron-sulfur (4Fe-4S) (By similarity)		C		1
METAL		90		90		Iron-sulfur (4Fe-4S) (By similarity)		C		1
METAL		162		162		Iron-sulfur (4Fe-4S) (By similarity)		C		1
BINDING		265		265		S-adenosyl-L-methionine (By similarity)		Q
BINDING		294		294		S-adenosyl-L-methionine; via carbonyl oxygen (By similarity)		F
BINDING		299		299		S-adenosyl-L-methionine (By similarity)		N
BINDING		315		315		S-adenosyl-L-methionine (By similarity)		E
BINDING		342		342		S-adenosyl-L-methionine (By similarity)		[ND]
BINDING		363		363		S-adenosyl-L-methionine (By similarity)		D

Size range:	431-514 amino acids
Related UniRules:	MF_01011 (TRMA)
Template:	P55135 (RLMD_ECOLI)
Scope:	Bacteria; Proteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None