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HAMAP annotation rule: MF_01012
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General rule information

Accession MF_01012
Dates 19-APR-2002 (Created)
11-NOV-2011 (Last updated, Version 19)
Data class Protein
Predictors HAMAP; MF_01012; [distribution of match scores in UniProtKB];[seed alignment for MF_01012]
Names 23SrRNA_methyltr_RlmC


Propagated annotation

Identifier, protein and gene names
Identifier RLMC
Protein name
RecName: Full=23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
EC=2.1.1.189;
AltName: Full=23S rRNA(m5U747)-methyltransferase;
Gene name rlmC
Comments
FUNCTION: Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity).
CATALYTIC ACTIVITY: S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.
SIMILARITY: Belongs to the methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Cross-references
Pfam PF05958; tRNA_U5-meth_tr; 1;
PROSITE PS01230; TRMA_1; 1;
PS01231; TRMA_2; 1;
TIGRFAMs TIGR02085; Meth_trns_rumB; 1;
Keywords
Methyltransferase, rRNA processing, S-adenosyl-L-methionine, Transferase.

case <FTGroup:1>
4Fe-4S, Iron, Iron-sulfur, Metal-binding.
end case

Gene Ontology
GO:0070041; Molecular function: rRNA (uridine-C5-)-methyltransferase activity.

case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case

GO:0031167; Biological process: rRNA methylation.
Features
From: RLMC_ECOLI (P75817)
Key     From     To       Description   Condition   FTGroup
ACT_SITE     334     334       Nucleophile (By similarity)   C  
 
METAL     3     3       Iron-sulfur (4Fe-4S) (By similarity)   C   1
METAL     11     11       Iron-sulfur (4Fe-4S) (By similarity)   C   1
METAL     14     14       Iron-sulfur (4Fe-4S) (By similarity)   C   1
METAL     87     87       Iron-sulfur (4Fe-4S) (By similarity)   C   1
 
BINDING     212     212       S-adenosyl-L-methionine (By similarity)   Q  
BINDING     241     241       S-adenosyl-L-methionine; via carbonyl oxygen (By similarity)   F  
BINDING     262     262       S-adenosyl-L-methionine (By similarity)   E  
BINDING     307     307       S-adenosyl-L-methionine (By similarity)   N  


Additional information

Size range: 375-392 amino acids
Related UniRules: None
Template: P75817 (RLMC_ECOLI); P55135 (RLMD_ECOLI): [Recover all]
Scope: Bacteria; Gammaproteobacteria
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences