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HAMAP annotation rule: MF_01014
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General rule information

Accession MF_01014
Dates 17-APR-2002 (Created)
11-OCT-2011 (Last updated, Version 34)
Data class Protein
Predictors HAMAP; MF_01014; [distribution of match scores in UniProtKB];[seed alignment for MF_01014]
Names HisA


Propagated annotation

Identifier, protein and gene names
Identifier HIS4

case not <OC:Mycobacteriaceae> and not <OC:Streptomycetaceae>
Protein name
RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
EC=5.3.1.16;
AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
Gene name hisA
end case


case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
Protein name
RecName: Full=Phosphoribosyl isomerase A;
AltName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
EC=5.3.1.16;
AltName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
Short=PRAI;
EC=5.3.1.24;
AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
Gene name priA, hisA
end case

Comments

case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
FUNCTION: Involved in both the histidine and tryptophan biosynthetic pathways (By similarity).
end case

CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide.

case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
CATALYTIC ACTIVITY: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
end case

PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.

case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.
end case

SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the HisA/HisF family.
Cross-references
Pfam PF00977; His_biosynth; 1;
TIGRFAMs TIGR00007; TIGR00007; 1;
Keywords
Cytoplasm, Isomerase, Amino-acid biosynthesis, Histidine biosynthesis.

case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
Aromatic amino acid biosynthesis, Tryptophan biosynthesis.
end case

Gene Ontology
GO:0003949; Molecular function: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity.

case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
GO:0004640; Molecular function: phosphoribosylanthranilate isomerase activity.
end case

GO:0000105; Biological process: histidine biosynthetic process.

case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
GO:0000162; Biological process: tryptophan biosynthetic process.
end case

GO:0005737; Cellular component: cytoplasm.
Features
From: HIS4_THEMA (Q9X0C7)
Key     From     To       Description   Condition   FTGroup
ACT_SITE     8     8       Proton acceptor (By similarity)   [DE]  
ACT_SITE     127     127       Proton donor (By similarity)   [DE]  


Additional information

Size range: 229-269 amino acids
Related UniRules: MF_01013 (HIS6)
Template: Q9X0C7 (HIS4_THEMA); P16250 (HIS4_STRCO); P60578 (HIS4_MYCTU): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in PHOLL, SILPO
Plasmid encoded: None

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UniProtKB rule member sequences