HAMAP

Accession	MF_01019
Dates	28-MAY-2002 (Created) 21-JAN-2011 (Last updated, Version 27)

Data class

Protein

Predictors

HAMAP; MF_01019; [distribution of match scores in UniProtKB];[seed alignment for MF_01019]

Names

HisIE

Identifier

HIS2

Protein name

RecName: Full=Histidine biosynthesis bifunctional protein HisIE; RecName: Full=Phosphoribosyl-AMP cyclohydrolase; Short=PRA-CH; EC=3.5.4.19; RecName: Full=Phosphoribosyl-ATP pyrophosphatase; Short=PRA-PH; EC=3.6.1.31;

Gene name

hisI, hisIE

CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-ATP + H(2)O = 1-(5-phosphoribosyl)-AMP + diphosphate.

CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide.

PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.

PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: In the N-terminal section; belongs to the PRA-CH family.

SIMILARITY: In the C-terminal section; belongs to the PRA-PH family.

Pfam	PF01502; PRA-CH; 1; PF01503; PRA-PH; 1;

Amino-acid biosynthesis, ATP-binding, Cytoplasm, Histidine biosynthesis, Hydrolase, Multifunctional enzyme, Nucleotide-binding.

GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity.
GO:0004636; Molecular function: phosphoribosyl-ATP diphosphatase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: HIS2_ECOLI (P06989)
Key		From		To		Description		Condition		FTGroup
REGION		Nter		114		Phosphoribosyl-AMP cyclohydrolase
REGION		115		Cter		Phosphoribosyl-ATP pyrophosphohydrolase

Size range:	197-231 amino acids
Related UniRules:	MF_01020 (HIS2); MF_01021 (HIS3)
Template:	P06989 (HIS2_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	See MF_01020 and MF_01021 for the entries relevant to hisI and hisE