HAMAP rule MF_01019
General rule information
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| Accession | MF_01019 |
| Dates | 28-MAY-2002 (Created)
28-JUN-2024 (Last updated, Version 33) |
| Name | HisIE |
| Scope(s) |
Bacteria Archaea |
| Template(s) | O82768 (HIS2_ARATH); P06989 (HIS2_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01019 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HIS2 |
| Protein name | RecName: Full=Histidine biosynthesis bifunctional protein HisIE; Includes: RecName: Full=Phosphoribosyl-AMP cyclohydrolase; Short=PRA-CH; EC=3.5.4.19; Includes: RecName: Full=Phosphoribosyl-ATP pyrophosphatase; Short=PRA-PH; EC=3.6.1.31; |
| Gene name | Name=hisI; Synonyms=hisIE; |
Comments
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| CATALYTIC ACTIVITY | Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D- ribosyl)-5'-AMP + diphosphate + H(+); Xref=Rhea:RHEA:22828, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:59457, ChEBI:CHEBI:73183; EC=3.6.1.31; |
| CATALYTIC ACTIVITY | Reaction=1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta- D-ribosyl)-5-[(5-phospho-beta-D- ribosylamino)methylideneamino]imidazole-4-carboxamide; Xref=Rhea:RHEA:20049, ChEBI:CHEBI:15377, ChEBI:CHEBI:58435, ChEBI:CHEBI:59457; EC=3.5.4.19; |
| PATHWAY | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. |
| PATHWAY | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | In the N-terminal section; belongs to the PRA-CH family. |
| SIMILARITY | In the C-terminal section; belongs to the PRA-PH family. |
Keywords
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| Amino-acid biosynthesis |
| ATP-binding |
| Cytoplasm |
| Histidine biosynthesis |
| Hydrolase |
| Multifunctional enzyme |
| Nucleotide-binding |
Gene Ontology
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| GO:0004635; Molecular function:phosphoribosyl-AMP cyclohydrolase activity |
| GO:0004636; Molecular function:phosphoribosyl-ATP diphosphatase activity |
| GO:0000105; Biological process:L-histidine biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: HIS2_ECOLI (P06989) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | Nter | 114 | /note="Phosphoribosyl-AMP cyclohydrolase" | |||||||||
| REGION | 115 | Cter | /note="Phosphoribosyl-ATP pyrophosphohydrolase" | |||||||||
Additional information
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| Size range | 184-300 amino acids |
| Related rules |
MF_01020 MF_01021 |
| Fusion | Nter: None Cter: None |
| Comments | See MF_01020 and MF_01021 for the entries relevant to hisI and hisE |