HAMAP

Accession	MF_01020
Dates	24-MAY-2002 (Created) 2-DEC-2011 (Last updated, Version 29)

Data class

Protein

Predictors

HAMAP; MF_01020; [distribution of match scores in UniProtKB];[seed alignment for MF_01020]

Names

HisE

Identifier

HIS2

Protein name

RecName: Full=Phosphoribosyl-ATP pyrophosphatase; Short=PRA-PH; EC=3.6.1.31;

Gene name

hisE

CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-ATP + H(2)O = 1-(5-phosphoribosyl)-AMP + diphosphate.

PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the PRA-PH family.

Pfam	PF01503; PRA-PH; 1;

Amino-acid biosynthesis, ATP-binding, Cytoplasm, Histidine biosynthesis, Hydrolase, Nucleotide-binding.

GO:0004636; Molecular function: phosphoribosyl-ATP diphosphatase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Size range:	87-160 amino acids
Related UniRules:	MF_01019 (HIS2 (supersedes the current rule))
Template:	P06989 (HIS2_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in BRAJA, RHOPA
Plasmid encoded:	None
Comments:	See MF_01019 for the entry relevant to the fused hisI-hisE