HAMAP rule MF_01020
General rule information
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| Accession | MF_01020 |
| Dates | 24-MAY-2002 (Created)
1-JUN-2023 (Last updated, Version 36) |
| Name | HisE |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P06989 (HIS2_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01020 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HIS2 |
| Protein name | RecName: Full=Phosphoribosyl-ATP pyrophosphatase; Short=PRA-PH; EC=3.6.1.31; |
| Gene name | Name=hisE; |
Comments
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| CATALYTIC ACTIVITY | Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D- ribosyl)-5'-AMP + diphosphate + H(+); Xref=Rhea:RHEA:22828, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:59457, ChEBI:CHEBI:73183; EC=3.6.1.31; |
| PATHWAY | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the PRA-PH family. |
Keywords
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Gene Ontology
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| GO:0004636; Molecular function:phosphoribosyl-ATP diphosphatase activity |
| GO:0000105; Biological process:histidine biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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Additional information
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| Size range | 87-160 amino acids |
| Related rules |
MF_01019 |
| Fusion | Nter: None Cter: None |
| Comments | See MF_01019 for the entry relevant to the fused hisI-hisE |