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HAMAP rule MF_01021

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General rule information [?]

Accession MF_01021
Dates 24-MAY-2002 (Created)
19-NOV-2022 (Last updated, Version 38)
Name HisI
Scope(s) Bacteria
Archaea
Template(s) O26347 (HIS3_METTH); Q50837 (HIS3_METVA); P06989 (HIS2_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01021 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HIS3
Protein name RecName: Full=Phosphoribosyl-AMP cyclohydrolase;
                 Short=PRA-CH;
                 EC=3.5.4.19;
Gene name Name=hisI;

Comments [?]

FUNCTIONCatalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
CATALYTIC ACTIVITY Reaction=1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta- D-ribosyl)-5-[(5-phospho-beta-D- ribosylamino)methylideneamino]imidazole-4-carboxamide; Xref=Rhea:RHEA:20049, ChEBI:CHEBI:15377, ChEBI:CHEBI:58435, ChEBI:CHEBI:59457; EC=3.5.4.19;
case <FTGroup:1>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
end case
case <FTGroup:2>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
PATHWAYAmino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
SUBUNITHomodimer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the PRA-CH family.

Keywords [?]

Amino-acid biosynthesis
Cytoplasm
Histidine biosynthesis
Hydrolase
case <FTGroup:1>
Magnesium
end case
case <FTGroup:2>
Zinc
end case
case <FTGroup:1> or <FTGroup:2>
Metal-binding
end case

Gene Ontology [?]

GO:0004635; Molecular function:phosphoribosyl-AMP cyclohydrolase activity
case <FTGroup:1>
GO:0000287; Molecular function:magnesium ion binding
end case
case <FTGroup:2>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0000105; Biological process:histidine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01502; PRA-CH; 1;

Features [?]

From: HIS3_METTH (O26347)
Key From To Description Tag Condition FTGroup
BINDING 85 85 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D 1
BINDING 86 86 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="ligand shared between dimeric partners"
C 2
BINDING 87 87 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D 1
BINDING 89 89 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D 1
BINDING 102 102 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="ligand shared between dimeric partners"
C 2
BINDING 109 109 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="ligand shared between dimeric partners"
C 2

Additional information [?]

Size range 101-180 amino acids
Related rules MF_01019
Fusion Nter: None Cter: None
Comments Possible wrong start in LEPIN and SACS2; not shown in alignment and not taken into account in size range. See MF_01019 for the entry relevant to the fused hisI-hisE.



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