HAMAP

Accession	MF_01021
Dates	24-MAY-2002 (Created) 2-DEC-2011 (Last updated, Version 28)

Data class

Protein

Predictors

HAMAP; MF_01021; [distribution of match scores in UniProtKB];[seed alignment for MF_01021]

Names

HisI

Identifier

HIS3

Protein name

RecName: Full=Phosphoribosyl-AMP cyclohydrolase; Short=PRA-CH; EC=3.5.4.19;

Gene name

hisI

CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide.

PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the PRA-CH family.

Pfam	PF01502; PRA-CH; 1;

Cytoplasm, Amino-acid biosynthesis, Histidine biosynthesis, Hydrolase.

GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Size range:	101-156 amino acids
Related UniRules:	MF_01019 (HIS2 (supersedes the current rule))
Template:	P06989 (HIS2_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in PSEF5
Plasmid encoded:	in ANAVT
Comments:	Possible wrong start in LEPIN and SULSO; not shown in alignment and not taken into account in size range. See MF_01019 for the entry relevant to the fused hisI-hisE.