HAMAP

Accession	MF_01022
Dates	14-JUN-2002 (Created) 11-OCT-2011 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_01022; [distribution of match scores in UniProtKB];[seed alignment for MF_01022]

Names

Bifunc_HisB

Identifier

HIS7

Protein name

RecName: Full=Histidine biosynthesis bifunctional protein hisB; RecName: Full=Histidinol-phosphatase; EC=3.1.3.15; RecName: Full=Imidazoleglycerol-phosphate dehydratase; Short=IGPD; EC=4.2.1.19;

Gene name

hisB

CATALYTIC ACTIVITY: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.

CATALYTIC ACTIVITY: L-histidinol phosphate + H(2)O = L-histidinol + phosphate.

PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.

PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: In the N-terminal section; belongs to the histidinol-phosphatase family.

SIMILARITY: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.

Pfam	PF00475; IGPD; 1;
TIGRFAMs	TIGR01662; HAD-SF-IIIA; 1; TIGR01261; HisB_Nterm; 1; TIGR01656; Histidinol-ppas; 1;
PROSITE	PS00954; IGP_DEHYDRATASE_1; 1; PS00955; IGP_DEHYDRATASE_2; 1;

Cytoplasm, Amino-acid biosynthesis, Histidine biosynthesis, Multifunctional enzyme, Lyase, Hydrolase.

GO:0004401; Molecular function: histidinol-phosphatase activity.
GO:0004424; Molecular function: imidazoleglycerol-phosphate dehydratase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: HIS7_ECOLI (P06987)
Key		From		To		Description		Condition		FTGroup
REGION		Nter		166		Histidinol-phosphatase
REGION		167		Cter		Imidazoleglycerol-phosphate dehydratase

Size range:	352-375 amino acids
Related UniRules:	MF_00076 (HIS7)
Template:	P06987 (HIS7_ECOLI)
Scope:	Bacteria; Bacteroidetes Bacteria; Proteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None