HAMAP

Accession	MF_01023
Dates	27-JUN-2002 (Created) 11-OCT-2011 (Last updated, Version 32)

Data class

Protein

Predictors

HAMAP; MF_01023; [distribution of match scores in UniProtKB];[seed alignment for MF_01023]

Names

HisC_aminotrans_2

Identifier

HIS8

Protein name

RecName: Full=Histidinol-phosphate aminotransferase; EC=2.6.1.9; AltName: Full=Imidazole acetol-phosphate transaminase;

Gene name

hisC

CATALYTIC ACTIVITY: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

COFACTOR: Pyridoxal phosphate (By similarity).

PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Pfam	PF00155; Aminotran_1_2; 1;
TIGRFAMs	TIGR01141; HisC; 1;
PROSITE	PS00599; AA_TRANSFER_CLASS_2; 1;

Amino-acid biosynthesis, Histidine biosynthesis, Transferase, Aminotransferase, Pyridoxal phosphate.

GO:0004400; Molecular function: histidinol-phosphate transaminase activity.
GO:0000105; Biological process: histidine biosynthetic process.

From: HIS8_ECOLI (P06986)
Key		From		To		Description		Condition		FTGroup
MOD_RES		214		214		N6-(pyridoxal phosphate)lysine (By similarity)		K

Size range:	335-401 amino acids
Related UniRules:	MF_01513 (PATR (supersedes the current rule))
Template:	P06986 (HIS8_ECOLI); Q9X0D0 (HIS8_THEMA): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: MF_01024 (hisD); Cter: None
Duplicate:	in NOSS1, ANAVT, ARCFU, BACAN, BACC1, BACCR, BACCZ, BACHK, BORBR, BORPA, BORPE, BRAJA, BURMA, BURP1, BURPS, BURS3, CARHZ, CAUCR, DECAR, GLUOX, HAEIN, HAEI8, IDILO, LEGPL, LEGPA, LEGPH, MANSM, METCA, NITEU, NITMU, NITOC, OCEIH, PASMU, PSEAE, PSEF5, PSEPF, PSYA2, CUPPJ, RALSO, RHILO, RHIME, THICR, THIDA
Plasmid encoded:	in RHIME, RHISN
Comments:	Shorter N-terminal in SULTO and in the first copy of hisC in ARCFU; not shown in alignment and not taken into account in size range. Difficulty to distinguish between hisC and other class-II pyridoxal-phosphate-dependent aminotransferases. PHOLL is a fusion between hisC and hisD. As other Enterobacteriaceae do not have such a fusion, this could be a sequencing artefact.