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HAMAP rule MF_01028

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General rule information [?]

Accession MF_01028
Dates 29-JUL-2002 (Created)
1-JUN-2023 (Last updated, Version 28)
Name CimA
Scope(s) Archaea
Template(s) Q58787 (CIMA_METJA); [ Recover all ]
Triggered by HAMAP; MF_01028 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CIMA
Protein name RecName: Full=Putative (R)-citramalate synthase CimA;
                 EC=2.3.3.21;
Gene name Name=cimA;

Comments [?]

FUNCTIONCatalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
CATALYTIC ACTIVITY Reaction=acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+); Xref=Rhea:RHEA:19045, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30934, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.3.21;
PATHWAYAmino-acid biosynthesis; L-isoleucine biosynthesis; 2- oxobutanoate from pyruvate: step 1/3.
SUBUNITHomodimer.
SIMILARITYBelongs to the alpha-IPM synthase/homocitrate synthase family.

Keywords [?]


Gene Ontology [?]

GO:0016747; Molecular function:acyltransferase activity, transferring groups other than amino-acyl groups
GO:0009097; Biological process:isoleucine biosynthetic process

Cross-references [?]

Pfam PF00682; HMGL-like; 1;
Pfam PF08502; LeuA_dimer; 1;
NCBIfam TIGR02090; LEU1_arch; 1;
PROSITE PS00815; AIPM_HOMOCIT_SYNTH_1; 1;
PROSITE PS00816; AIPM_HOMOCIT_SYNTH_2; 1;
PROSITE PS50991; PYR_CT; 1;

Features [?]


Additional information [?]

Size range 483-529 amino acids
Related rules MF_01025
MF_00572
Fusion Nter: None Cter: None
Comments Difficulty to distinguish between LeuA, CimA and AksA subfamilies.



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