HAMAP

Accession	MF_01028
Dates	29-JUL-2002 (Created) 16-MAR-2011 (Last updated, Version 21)

Data class

Protein

Predictors

HAMAP; MF_01028; [distribution of match scores in UniProtKB];[seed alignment for MF_01028]

Names

CimA

Identifier

CIMA

Protein name

RecName: Full=Putative (R)-citramalate synthase CimA; EC=2.3.1.182;

Gene name

cimA

FUNCTION: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate (By similarity).

CATALYTIC ACTIVITY: Acetyl-CoA + pyruvate + H(2)O = CoA + (2R)-2-hydroxy-2-methylbutanedioate.

PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the alpha-IPM synthase/homocitrate synthase family.

Pfam	PF00682; HMGL-like; 1; PF08502; LeuA_dimer; 1;
TIGRFAMs	TIGR02090; LEU1_arch; 1;
PROSITE	PS00815; AIPM_HOMOCIT_SYNTH_1; 1; PS00816; AIPM_HOMOCIT_SYNTH_2; 1; PS50991; PYR_CT; 1;

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesis, Transferase.

GO:0016747; Molecular function: transferase activity, transferring acyl groups other than amino-acyl groups.
GO:0009097; Biological process: isoleucine biosynthetic process.

Size range:	483-529 amino acids
Related UniRules:	MF_01025 (LEU1); MF_00572 (LEU1)
Template:	Q58787 (CIMA_METJA)
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Difficulty to distinguish between LeuA, CimA and AksA subfamilies.