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HAMAP rule MF_01043

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General rule information [?]

Accession MF_01043
Dates 24-JAN-2003 (Created)
28-NOV-2023 (Last updated, Version 51)
Name PlsY
Scope(s) Bacteria
Template(s) P60782 (PLSY_ECOLI); Q45064 (PLSY_BACSU); P0A4Q0 (PLSY_STRR6); [ Recover all ]
Triggered by HAMAP; MF_01043 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PLSY
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
Protein name RecName: Full=Glycerol-3-phosphate acyltransferase;
AltName: Full=G3P acyltransferase;
                 Short=GPAT;
                 EC=2.3.1.15;
                 EC=2.3.1.n5;
AltName: Full=Lysophosphatidic acid synthase;
                 Short=LPA synthase;
else
Protein name RecName: Full=Glycerol-3-phosphate acyltransferase;
AltName: Full=Acyl-PO4 G3P acyltransferase;
AltName: Full=Acyl-phosphate--glycerol-3-phosphate acyltransferase;
AltName: Full=G3P acyltransferase;
                 Short=GPAT;
                 EC=2.3.1.275;
AltName: Full=Lysophosphatidic acid synthase;
                 Short=LPA synthase;
end case
Gene name Name=plsY;

Comments [?]

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
FUNCTIONCatalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl- PO(4).
CATALYTIC ACTIVITY Reaction=an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3- phosphate + CoA; Xref=Rhea:RHEA:15325, ChEBI:CHEBI:57287, ChEBI:CHEBI:57597, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342; EC=2.3.1.15;
CATALYTIC ACTIVITY Reaction=a fatty acyl-[ACP] + sn-glycerol 3-phosphate = a 1-acyl-sn- glycero-3-phosphate + holo-[ACP]; Xref=Rhea:RHEA:42300, Rhea:RHEA- COMP:9685, Rhea:RHEA-COMP:14125, ChEBI:CHEBI:57597, ChEBI:CHEBI:57970, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651; EC=2.3.1.n5;
else
FUNCTIONCatalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
CATALYTIC ACTIVITY Reaction=an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn- glycero-3-phosphate + phosphate; Xref=Rhea:RHEA:34075, ChEBI:CHEBI:43474, ChEBI:CHEBI:57597, ChEBI:CHEBI:57970, ChEBI:CHEBI:59918; EC=2.3.1.275;
end case
PATHWAYLipid metabolism; phospholipid metabolism.
SUBUNITProbably interacts with PlsX.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the PlsY family.

Keywords [?]


Gene Ontology [?]

case <OCellular component:Escherichia> or <OC:Shigella> or <OC:Salmonella>
GO:0004366; Molecular function:glycerol-3-phosphate O-acyltransferase activity
end case
case not <OCellular component:Escherichia> and not <OC:Shigella> and not <OC:Salmonella>
GO:0043772; Molecular function:acyl-phosphate glycerol-3-phosphate acyltransferase activity
end case
GO:0008654; Biological process:phospholipid biosynthetic process

Cross-references [?]

Pfam PF02660; G3P_acyltransf; 1;
NCBIfam TIGR00023; TIGR00023; 1;
General Transmembrane; -; 4-6;

Features [?]

From: PLSY_ECOLI (P60782)
Key From To Description Tag Condition FTGroup
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
TOPO_DOM 1 3 /note="Periplasmic"
TRANSMEM 4 24 /note="Helical"
TOPO_DOM 25 52 /note="Cytoplasmic"
TRANSMEM 53 73 /note="Helical"
TOPO_DOM 74 80 /note="Periplasmic"
TRANSMEM 81 101 /note="Helical"
TOPO_DOM 102 111 /note="Cytoplasmic"
TRANSMEM 112 132 /note="Helical"
TOPO_DOM 133 137 /note="Periplasmic"
TRANSMEM 138 158 /note="Helical"
TOPO_DOM 159 205 /note="Cytoplasmic"
end case

Additional information [?]

Size range 172-327 amino acids
Related rules None
Fusion Nter: None Cter: None



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