HAMAP

Accession	MF_01046
Dates	13-FEB-2003 (Created) 2-DEC-2011 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_01046; [distribution of match scores in UniProtKB];[seed alignment for MF_01046]

Names

Chaperone_HchA

Identifier

HCHA

Protein name

RecName: Full=Chaperone protein hchA; AltName: Full=Hsp31;

Gene name

hchA

FUNCTION: Uses temperature-induced exposure of structured hydrophobic domains to capture and stabilize early unfolding protein intermediates under severe thermal stress. It rapidly releases them once stress has abated (By similarity).

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

INDUCTION: By heat shock (By similarity).

SIMILARITY: Belongs to the peptidase C56 family. HchA subfamily.

Pfam	PF01965; DJ-1_PfpI; 1;
PIRSF	PIRSF037798; Chaperone_HchA; 1;

Cytoplasm, Chaperone.

Stress response.

Metal-binding, Zinc.

GO:0051082; Molecular function: unfolded protein binding.

GO:0008270; Molecular function: zinc ion binding.

GO:0042026; Biological process: protein refolding.
GO:0005737; Cellular component: cytoplasm.

From: HCHA_ECOLI (P31658)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		185		185		By similarity		C
ACT_SITE		186		186		By similarity		H
ACT_SITE		214		214		By similarity		D
METAL (Optional)		86		86		Zinc (By similarity)		H		1
METAL (Optional)		91		91		Zinc (By similarity)		E		1
METAL (Optional)		123		123		Zinc (By similarity)		H		1

Size range:	282-292 amino acids
Related UniRules:	None
Template:	P31658 (HCHA_ECOLI)
Scope:	Bacteria; Staphylococcus Bacteria; Gammaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None