HAMAP rule MF_01049
General rule information
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Accession | MF_01049 |
Dates | 13-FEB-2003 (Created)
1-JUN-2023 (Last updated, Version 34) |
Name | CaiT |
Scope(s) |
Bacteria Enterobacterales |
Template(s) | P31553 (CAIT_ECOLI); B4EY22 (CAIT_PROMH); [ Recover all ] |
Triggered by |
HAMAP; MF_01049 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | CAIT |
Protein name | RecName: Full=L-carnitine/gamma-butyrobetaine antiporter; |
Gene name | Name=caiT; |
Comments
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FUNCTION | Catalyzes the exchange of L-carnitine for gamma- butyrobetaine. |
CATALYTIC ACTIVITY | Reaction=(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) = (R)- carnitine(in) + 4-(trimethylamino)butanoate(out); Xref=Rhea:RHEA:29427, ChEBI:CHEBI:16244, ChEBI:CHEBI:16347; |
PATHWAY | Amine and polyamine metabolism; carnitine metabolism. |
SUBUNIT | Homotrimer. |
case not defined <Property:Membrane> or <Property:Membrane=1> | |
SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2> | |
SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
end case | |
SIMILARITY | Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily. |
Keywords
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Transport | |
Antiport | |
Membrane | |
Transmembrane | |
case defined <Property:Membrane> and <Property:Membrane=2> | |
Cell inner membrane | |
end case | |
Cell membrane | |
Transmembrane helix |
Gene Ontology
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GO:0044667; Molecular function:(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity |
GO:1902603; Biological process:carnitine transmembrane transport |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF02028; BCCT; 1; |
NCBIfam | TIGR00842; bcct; 1; |
PROSITE | PS01303; BCCT; 1; |
General | Transmembrane; -; 12; |
Features
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Additional information
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Size range | 504-505 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |