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HAMAP rule MF_01049

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General rule information [?]

Accession MF_01049
Dates 13-FEB-2003 (Created)
1-JUN-2023 (Last updated, Version 34)
Name CaiT
Scope(s) Bacteria
Enterobacterales
Template(s) P31553 (CAIT_ECOLI); B4EY22 (CAIT_PROMH); [ Recover all ]
Triggered by HAMAP; MF_01049 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CAIT
Protein name RecName: Full=L-carnitine/gamma-butyrobetaine antiporter;
Gene name Name=caiT;

Comments [?]

FUNCTIONCatalyzes the exchange of L-carnitine for gamma- butyrobetaine.
CATALYTIC ACTIVITY Reaction=(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) = (R)- carnitine(in) + 4-(trimethylamino)butanoate(out); Xref=Rhea:RHEA:29427, ChEBI:CHEBI:16244, ChEBI:CHEBI:16347;
PATHWAYAmine and polyamine metabolism; carnitine metabolism.
SUBUNITHomotrimer.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily.

Keywords [?]

Transport
Antiport
Membrane
Transmembrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Transmembrane helix

Gene Ontology [?]

GO:0044667; Molecular function:(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity
GO:1902603; Biological process:carnitine transmembrane transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF02028; BCCT; 1;
NCBIfam TIGR00842; bcct; 1;
PROSITE PS01303; BCCT; 1;
General Transmembrane; -; 12;

Features [?]


Additional information [?]

Size range 504-505 amino acids
Related rules None
Fusion Nter: None Cter: None



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