HAMAP rule MF_01050
General rule information
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Accession | MF_01050 |
Dates | 12-MAR-2003 (Created)
15-DEC-2022 (Last updated, Version 24) |
Name | CaiB |
Scope(s) |
Bacteria Enterobacterales |
Template(s) | P31572 (CAIB_ECOLI); Q8GB19 (CAIB_PROSL); [ Recover all ] |
Triggered by |
HAMAP; MF_01050 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | CAIB |
Protein name | RecName: Full=L-carnitine CoA-transferase; EC=2.8.3.21; AltName: Full=Crotonobetainyl-CoA:carnitine CoA-transferase; |
Gene name | Name=caiB; |
Comments
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FUNCTION | Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L- carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA. |
CATALYTIC ACTIVITY | Reaction=(R)-carnitine + crotonobetainyl-CoA = (R)-carnitinyl-CoA + crotonobetaine; Xref=Rhea:RHEA:28526, ChEBI:CHEBI:16347, ChEBI:CHEBI:17237, ChEBI:CHEBI:60932, ChEBI:CHEBI:60933; EC=2.8.3.21; |
CATALYTIC ACTIVITY | Reaction=(R)-carnitine + 4-(trimethylamino)butanoyl-CoA = (R)- carnitinyl-CoA + 4-(trimethylamino)butanoate; Xref=Rhea:RHEA:28418, ChEBI:CHEBI:16244, ChEBI:CHEBI:16347, ChEBI:CHEBI:60932, ChEBI:CHEBI:61513; EC=2.8.3.21; |
PATHWAY | Amine and polyamine metabolism; carnitine metabolism. |
SUBUNIT | Homodimer. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the CoA-transferase III family. CaiB subfamily. |
Keywords
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Gene Ontology
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GO:0008410; Molecular function:CoA-transferase activity |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF02515; CoA_transf_3; 1; |
Features
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From: CAIB_ECOLI (P31572) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 169 | 169 | /note="Nucleophile" | D | ||||||||
BINDING | 97 | 97 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
K | ||||||||
BINDING | 104 | 104 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
R |
Additional information
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Size range | 405-406 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |