Annotation rule MF_01057
Send feedback

General rule information [?]

Accession MF_01057
Dates 12-JUN-2003 (Created)
19-OCT-2016 (Last updated, Version 24)
Name tRNA_methyltr_TrmB
Scope Bacteria
Templates P0A8I5 (TRMB_ECOLI); O34522 (TRMB_BACSU); P67506 (TRMB_STRPN); O66479 (TRMB_AQUAE): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=tRNA (guanine-N(7)-)-methyltransferase;
AltName: Full=tRNA (guanine(46)-N(7))-methyltransferase;
AltName: Full=tRNA(m7G46)-methyltransferase;
Gene name

Comments [?]

Function Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Catalytic activity S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.
Pathway tRNA modification; N(7)-methylguanine-tRNA biosynthesis.
case <OC:Enterobacterales>
Subunit Monomer.
end case
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

Keywords [?]

Gene Ontology [?]

GO:0008176; Molecular function: tRNA (guanine-N7-)-methyltransferase activity.
GO:0006400; Biological process: tRNA modification.

Cross-references [?]

Pfam PF02390; Methyltransf_4; 1;
TIGRFAMs TIGR00091; TIGR00091; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     150     155       Interaction with RNA     [KR]-[KH]-[EN]-K-R-R  
REGION (Optional)     217     220       Substrate binding     T-x-[YF]-E  
BINDING (Optional)     69     69       S-adenosyl-L-methionine     [DE]  
BINDING (Optional)     94     94       S-adenosyl-L-methionine     [DE]  
BINDING (Optional)     121     121       S-adenosyl-L-methionine     [DEN]  
BINDING (Optional)     144     144       S-adenosyl-L-methionine     [DN]  
BINDING (Optional)     148     148       Substrate     K  
BINDING (Optional)     180     180       Substrate     D  

Additional information [?]

Size range 185-400 amino acids
Related rules None
Fusion Nter: hemK, kdtA; Cter: None
Comments Fused to hemK in RICBR, RICCN, RICFE, RICPR and RICTY, and fused to kdtA in FUSNN; Unknown N-terminal domain in METPP; sequences not included in alignment and not taken into account in size range