HAMAP rule MF_01074
General rule information
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| Accession | MF_01074 |
| Dates | 30-JUL-2003 (Created)
3-SEP-2024 (Last updated, Version 27) |
| Name | LarC |
| Scope(s) |
Bacteria Archaea |
| Template(s) | F9UST1 (LARC_LACPL); [ Recover all ] |
| Triggered by |
HAMAP; MF_01074 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae> | |
| Identifier | LARC |
| Protein name | RecName: Full=Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein; Short=P2TMN nickel insertion protein; EC=4.99.1.12; AltName: Full=Nickel-pincer cofactor biosynthesis protein LarC; |
| Gene name | Name=larC; |
| else | |
| Identifier | Ynnn |
| Protein name | RecName: Full=Putative nickel insertion protein; |
| end case | |
Comments
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| case <OC:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae> | |
| FUNCTION | Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. |
| CATALYTIC ACTIVITY | Reaction=Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = pyridinium-3,5-bisthiocarboxylate mononucleotide + Ni(2+); Xref=Rhea:RHEA:54784, ChEBI:CHEBI:49786, ChEBI:CHEBI:137372, ChEBI:CHEBI:137373; EC=4.99.1.12; |
| end case | |
| SIMILARITY | Belongs to the LarC family. |
Keywords
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Gene Ontology
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| GO:0016151; Molecular function:nickel cation binding | |
| GO:0016829; Molecular function:lyase activity | |
| case <OCellular component:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae> | |
| GO:0051604; Biological process:protein maturation | |
| end case | |
Cross-references
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Features
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Additional information
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| Size range | 379-516 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Shorter N-terminal in ENTFA; not shown in alignment and not taken into account in size range |