HAMAP rule MF_01075
General rule information
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Accession | MF_01075 |
Dates | 11-AUG-2003 (Created)
29-SEP-2022 (Last updated, Version 36) |
Name | NhaP2 |
Scope(s) |
Bacteria Gammaproteobacteria |
Template(s) | A5F4U3 (NHAP2_VIBC3); Q87KV8 (NHAP2_VIBPA); P76007 (NHAP2_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01075 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | NHAP2 |
Protein name | RecName: Full=K(+)/H(+) antiporter NhaP2; AltName: Full=Potassium/proton antiporter NhaP2; |
Gene name | Name=nhaP2; |
Comments
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FUNCTION | K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels. |
CATALYTIC ACTIVITY | Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out); Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29468; |
case not defined <Property:Membrane> or <Property:Membrane=1> | |
SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2> | |
SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
end case | |
SIMILARITY | Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. |
Keywords
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Antiport | |
case defined <Property:Membrane> and <Property:Membrane=2> | |
Cell inner membrane | |
end case | |
Cell membrane | |
Ion transport | |
Membrane | |
Potassium | |
Potassium transport | |
Transmembrane | |
Transmembrane helix | |
Transport |
Gene Ontology
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GO:0015386; Molecular function:potassium:proton antiporter activity |
GO:0015079; Molecular function:potassium ion transmembrane transporter activity |
GO:0071805; Biological process:potassium ion transmembrane transport |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF03471; CorC_HlyC; 1; |
Pfam | PF00999; Na_H_Exchanger; 1; |
Pfam | PF02080; TrkA_C; 1; |
PROSITE | PS51202; RCK_C; 1; |
General | Transmembrane; -; 10-13; |
Features
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Additional information
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Size range | 538-640 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |