HAMAP rule MF_01082
General rule information
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| Accession | MF_01082 |
| Dates | 26-SEP-2003 (Created)
1-JUN-2023 (Last updated, Version 29) |
| Name | TruD |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q57261 (TRUD_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01082 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TRUD |
| case <OC:Bacteria> | |
| Protein name | RecName: Full=tRNA pseudouridine synthase D; EC=5.4.99.27; AltName: Full=tRNA pseudouridine(13) synthase; AltName: Full=tRNA pseudouridylate synthase D; AltName: Full=tRNA-uridine isomerase D; |
| end case | |
| case <OC:Archaea> | |
| Protein name | RecName: Full=Probable tRNA pseudouridine synthase D; EC=5.4.99.27; AltName: Full=tRNA pseudouridine(13) synthase; AltName: Full=tRNA pseudouridylate synthase D; AltName: Full=tRNA-uridine isomerase D; |
| end case | |
| Gene name | Name=truD; |
Comments
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| case <OC:Bacteria> | |
| FUNCTION | Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. |
| end case | |
| case <OC:Archaea> | |
| FUNCTION | Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=uridine(13) in tRNA = pseudouridine(13) in tRNA; Xref=Rhea:RHEA:42540, Rhea:RHEA-COMP:10105, Rhea:RHEA-COMP:10106, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.27; |
| SIMILARITY | Belongs to the pseudouridine synthase TruD family. |
Keywords
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Gene Ontology
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| GO:0009982; Molecular function:pseudouridine synthase activity |
| GO:0031119; Biological process:tRNA pseudouridine synthesis |
Cross-references
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| Pfam | PF01142; TruD; 1; |
| NCBIfam | TIGR00094; TRNA_TruD_broad; 1; |
| PROSITE | PS50984; TRUD; 1; |
| PROSITE | PS01268; UPF0024; 1; |
Features
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| From: TRUD_ECOLI (Q57261) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 80 | 80 | /note="Nucleophile" | D | ||||||||
| case <OC:Enterobacterales> | ||||||||||||
| BINDING | 27 | 27 | /ligand="substrate" | F | ||||||||
| BINDING | 129 | 129 | /ligand="substrate" | N | ||||||||
| BINDING | 329 | 329 | /ligand="substrate" | F | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 335-460 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |