HAMAP

Accession	MF_01105
Dates	10-FEB-2003 (Created) 2-DEC-2011 (Last updated, Version 29)

Data class

Protein

Predictors

HAMAP; MF_01105; [distribution of match scores in UniProtKB];[seed alignment for MF_01105]

Names

N-acetyl_glu_synth

Identifier

ARGA

Protein name

RecName: Full=Amino-acid acetyltransferase; EC=2.3.1.1; AltName: Full=N-acetylglutamate synthase; Short=AGS; Short=NAGS;

Gene name

argA

CATALYTIC ACTIVITY: Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.

PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.

SUBUNIT: Homohexamer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

MISCELLANEOUS: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

SIMILARITY: Belongs to the acetyltransferase family. ArgA subfamily.

Pfam	PF00696; AA_kinase; 1; PF00583; Acetyltransf_1; 1;
PIRSF	PIRSF000423; ArgA; 1;
TIGRFAMs	TIGR01890; N-Ac-Glu-synth; 1;
PROSITE	PS51186; GNAT; 1; trigger=PRU00532;

Cytoplasm, Amino-acid biosynthesis, Arginine biosynthesis, Transferase, Acyltransferase.

GO:0004042; Molecular function: acetyl-CoA:L-glutamate N-acetyltransferase activity.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Size range:	432-451 amino acids
Related UniRules:	None
Template:	P0A6C5 (ARGA_ECOLI)
Scope:	Bacteria; Proteobacteria
Fusion:	Nter: MF_00006 (argH); Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Moritella sp. argA is fusioned in its N-terminal part to argH. The NAT domain is not shown here - it is much smaller than other acetylglutamate synthases.