HAMAP

Accession	MF_01106
Dates	28-MAR-2003 (Created) 4-JAN-2011 (Last updated, Version 30)

Data class

Protein

Predictors

HAMAP; MF_01106; [distribution of match scores in UniProtKB];[seed alignment for MF_01106]

Names

ArgJ

Identifier

ARGJ

Protein name

RecName: Full=Arginine biosynthesis bifunctional protein ArgJ; RecName: Full=Glutamate N-acetyltransferase; EC=2.3.1.35; AltName: Full=Ornithine acetyltransferase; Short=OATase; AltName: Full=Ornithine transacetylase; RecName: Full=Amino-acid acetyltransferase; EC=2.3.1.1; AltName: Full=N-acetylglutamate synthase; Short=AGS; RecName: Full=Arginine biosynthesis bifunctional protein ArgJ alpha chain; RecName: Full=Arginine biosynthesis bifunctional protein ArgJ beta chain;

Gene name

argJ

FUNCTION: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate (By similarity).

CATALYTIC ACTIVITY: N(2)-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate.

CATALYTIC ACTIVITY: Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.

PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.

PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.

SUBUNIT: Heterotetramer of two alpha and two beta chains (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

MISCELLANEOUS: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

SIMILARITY: Belongs to the ArgJ family.

Pfam	PF01960; ArgJ; 1;
TIGRFAMs	TIGR00120; ArgJ; 1;

Cytoplasm, Amino-acid biosynthesis, Arginine biosynthesis, Autocatalytic cleavage, Multifunctional enzyme, Transferase, Acyltransferase.

GO:0004042; Molecular function: acetyl-CoA:L-glutamate N-acetyltransferase activity.
GO:0004358; Molecular function: glutamate N-acetyltransferase activity.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: ARGJ_GEOSE (Q07908)
Key		From		To		Description		Condition		FTGroup
CHAIN		Nter		196		Arginine biosynthesis bifunctional protein ArgJ alpha chain (By similarity)
CHAIN		197		Cter		Arginine biosynthesis bifunctional protein ArgJ beta chain (By similarity)
SITE		196		197		Cleavage; by autolysis (By similarity)		A-T

Size range:	379-432 amino acids
Related UniRules:	None
Template:	Q07908 (ARGJ_GEOSE)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in NOSS1, CLOAB
Plasmid encoded:	None