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HAMAP rule MF_01108

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General rule information [?]

Accession MF_01108
Dates 27-MAR-2003 (Created)
1-JUN-2023 (Last updated, Version 39)
Name ArgE
Scope(s) Bacteria
Enterobacterales
Vibrionales
Template(s) P23908 (ARGE_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01108 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ARGE
Protein name RecName: Full=Acetylornithine deacetylase;
                 Short=AO;
                 Short=Acetylornithinase;
                 EC=3.5.1.16;
AltName: Full=N-acetylornithinase;
                 Short=NAO;
Gene name Name=argE;

Comments [?]

FUNCTIONCatalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids. Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
CATALYTIC ACTIVITY Reaction=H2O + N(2)-acetyl-L-ornithine = acetate + L-ornithine; Xref=Rhea:RHEA:15941, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:46911, ChEBI:CHEBI:57805; EC=3.5.1.16;
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Note=Binds 2 Zn(2+) or Co(2+) ions per subunit.;
COFACTOR Name=glutathione; Xref=ChEBI:CHEBI:57925;
PATHWAYAmino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1.
SUBUNITHomodimer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the peptidase M20A family. ArgE subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008777; Molecular function:acetylornithine deacetylase activity
GO:0008270; Molecular function:zinc ion binding
GO:0006526; Biological process:arginine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01546; Peptidase_M20; 1;
NCBIfam TIGR01892; AcOrn-deacetyl; 1;
PROSITE PS00758; ARGE_DAPE_CPG2_1; 1;
PROSITE PS00759; ARGE_DAPE_CPG2_2; 1;

Features [?]

From: ARGE_ECOLI (P23908)
Key From To Description Tag Condition FTGroup
ACT_SITE 82 82 D
ACT_SITE 144 144 E
BINDING 80 80 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="1"
H
BINDING 112 112 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="1"
D
BINDING 112 112 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="2"
D
BINDING 145 145 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="2"
E
BINDING 169 169 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="1"
E
BINDING 355 355 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="2"
H

Additional information [?]

Size range 378-389 amino acids
Related rules None
Fusion Nter: None Cter: None



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