HAMAP rule MF_01108
General rule information
[?]
Accession | MF_01108 |
Dates | 27-MAR-2003 (Created)
1-JUN-2023 (Last updated, Version 39) |
Name | ArgE |
Scope(s) |
Bacteria Enterobacterales Vibrionales |
Template(s) | P23908 (ARGE_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01108 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier | ARGE |
Protein name | RecName: Full=Acetylornithine deacetylase; Short=AO; Short=Acetylornithinase; EC=3.5.1.16; AltName: Full=N-acetylornithinase; Short=NAO; |
Gene name | Name=argE; |
Comments
[?]
FUNCTION | Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids. Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines. |
CATALYTIC ACTIVITY | Reaction=H2O + N(2)-acetyl-L-ornithine = acetate + L-ornithine; Xref=Rhea:RHEA:15941, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:46911, ChEBI:CHEBI:57805; EC=3.5.1.16; |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Note=Binds 2 Zn(2+) or Co(2+) ions per subunit.; |
COFACTOR | Name=glutathione; Xref=ChEBI:CHEBI:57925; |
PATHWAY | Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1. |
SUBUNIT | Homodimer. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the peptidase M20A family. ArgE subfamily. |
Keywords
[?]
Gene Ontology
[?]
GO:0008777; Molecular function:acetylornithine deacetylase activity |
GO:0008270; Molecular function:zinc ion binding |
GO:0006526; Biological process:arginine biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
[?]
Pfam | PF01546; Peptidase_M20; 1; |
NCBIfam | TIGR01892; AcOrn-deacetyl; 1; |
PROSITE | PS00758; ARGE_DAPE_CPG2_1; 1; |
PROSITE | PS00759; ARGE_DAPE_CPG2_2; 1; |
Features
[?]
From: ARGE_ECOLI (P23908) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 82 | 82 | D | |||||||||
ACT_SITE | 144 | 144 | E | |||||||||
BINDING | 80 | 80 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
H | ||||||||
BINDING | 112 | 112 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
D | ||||||||
BINDING | 112 | 112 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
D | ||||||||
BINDING | 145 | 145 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
E | ||||||||
BINDING | 169 | 169 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
E | ||||||||
BINDING | 355 | 355 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
H |
Additional information
[?]
Size range | 378-389 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |