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HAMAP annotation rule: MF_01109
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General rule information

Accession MF_01109
Dates 11-JUL-2003 (Created)
11-OCT-2011 (Last updated, Version 29)
Data class Protein
Predictors HAMAP; MF_01109; [distribution of match scores in UniProtKB];[seed alignment for MF_01109]
Names OTCase


Propagated annotation

Identifier, protein and gene names
Identifier OTC
Protein name
RecName: Full=Ornithine carbamoyltransferase;
Short=OTCase;
EC=2.1.3.3;

case not <Property:ARGININE_BS>
Identifier OTCC
Protein name
RecName: Full=Ornithine carbamoyltransferase, catabolic;
Short=OTCase;
EC=2.1.3.3;
end case


case <Property:ARGININE_BS> and <OC:Enterobacteriaceae>
Gene name argI
end case


case <Property:ARGININE_BS> and not <OC:Enterobacteriaceae>
Gene name argF
end case


case not <Property:ARGININE_BS>
Gene name arcB
end case

Comments
CATALYTIC ACTIVITY: Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

case <Property:ARGININE_BS>
PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.
end case


case not <Property:ARGININE_BS>
PATHWAY: Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2.
end case

SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the ATCase/OTCase family.
Cross-references
Pfam PF00185; OTCace; 1;
PF02729; OTCace_N; 1;
PRINTS PR00100; AOTCASE; 1;
TIGRFAMs TIGR00658; Orni_carb_tr; 1;
PROSITE PS00097; CARBAMOYLTRANSFERASE; 1;
Keywords

case <Property:ARGININE_BS>
Amino-acid biosynthesis, Arginine biosynthesis.
end case


case not <Property:ARGININE_BS>
Arginine metabolism.
end case

Cytoplasm, Transferase.
Gene Ontology
GO:0004585; Molecular function: ornithine carbamoyltransferase activity.

case <Property:ARGININE_BS>
GO:0006526; Biological process: arginine biosynthetic process.
end case


case not <Property:ARGININE_BS>
GO:0019546; Biological process: arginine deiminase pathway.
end case

GO:0005737; Cellular component: cytoplasm.
Features
From: OTCC_PSEAE (P08308)
Key     From     To       Description   Condition   FTGroup
REGION     57     61       Carbamoyl phosphate binding (By similarity)   S-T-R-T-R  
REGION     273     276       Ornithine binding (By similarity)   H-C-L-P  
BINDING     108     108       Carbamoyl phosphate (By similarity)   R  
BINDING     135     135       Carbamoyl phosphate (By similarity)   H  
SITE (Optional)     32     32       Important for structural integrity (By similarity)   K  
SITE (Optional)     148     148       Important for structural integrity (By similarity)   E  


Additional information

Size range: 295-354 amino acids
Related UniRules: MF_02102 (PTC (supersedes the current rule))
Template: P04391 (OTC1_ECOLI)
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in ECOL6, LACLA, PSEAE, PSEPK, RHIME, SALTI, SALTY, STAAM, STAAN, STAAW, STAES, STRA3, STRA5
Plasmid encoded: in HALSA, RHIME
Comments: OTCases can be involved in the biosynthesis of arginine and in its catabolism, by the arginine deiminase pathway. Some bacteria possess two distinct OTCases; some do not degrade arginine using this pathway and others do not synthesize arginine. As it is impossible to distinguish between anabolic and catabolic OTCases based on sequence similarity alone, if paralogs are found in a given genome, then one is probably the anabolic enzyme and the other the catabolic one, named arcB, which is usually located in the arcABC operon. E.coli K-12 carries two genes for anabolic OTCase, argF and argI; their products interact to form a family of four trimeric isoenzymes. Only argI can be found in E.coli B, E.coli W or in other enterobacteria.

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UniProtKB rule member sequences