HAMAP

Accession	MF_01120
Dates	24-DEC-2003 (Created) 31-OCT-2011 (Last updated, Version 22)

Data class

Protein

Predictors

HAMAP; MF_01120; [distribution of match scores in UniProtKB];[seed alignment for MF_01120]

Names

Acet-lys_deacetyl

Identifier

LYSK

Protein name

RecName: Full=Acetyl-lysine deacetylase; EC=3.5.1.-;

Gene name

lysK

CATALYTIC ACTIVITY: N(2)-acetyl-L-lysine + H(2)O = acetate + L-lysine.

COFACTOR: Binds 2 zinc or cobalt ions per subunit (By similarity).

COFACTOR: Glutathione (By similarity).

PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5.

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the peptidase M20A family. LysK subfamily.

Pfam	PF01546; Peptidase_M20; 1;
TIGRFAMs	TIGR01902; DapE-lys-deAc; 1; TIGR01910; DapE-ArgE; 1;
PROSITE	PS00758; ARGE_DAPE_CPG2_1; 1;

Cytoplasm, Amino-acid biosynthesis, Lysine biosynthesis, Hydrolase, Metal-binding, Cobalt, Zinc.

GO:0008270; Molecular function: zinc ion binding.
GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.
GO:0009085; Biological process: lysine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: LYSK_SULSO (Q980W5)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		70		70		By similarity		D
ACT_SITE		122		122		Proton acceptor (By similarity)		E
METAL		68		68		Cobalt or zinc 1 (By similarity)		H
METAL		92		92		Cobalt or zinc 1 (By similarity)		D
METAL		92		92		Cobalt or zinc 2 (By similarity)		D
METAL		123		123		Cobalt or zinc 2 (By similarity)		E
METAL		146		146		Cobalt or zinc 1 (By similarity)		E
METAL		317		317		Cobalt or zinc 2 (By similarity)		H

Size range:	325-362 amino acids
Related UniRules:	None
Template:	Q980W5 (LYSK_SULSO)
Scope:	Bacteria; Deinococci Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None