HAMAP rule MF_01124
General rule information
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| Accession | MF_01124 |
| Dates | 11-DEC-2003 (Created)
17-JAN-2023 (Last updated, Version 15) |
| Name | MecA |
| Scope(s) |
Bacteria Bacillota |
| Template(s) | P37958 (MECA1_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01124 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MECA |
| Protein name | RecName: Full=Adapter protein MecA; |
| Gene name | Name=mecA; |
Comments
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| case <OC:Bacillaceae> | |
| FUNCTION | Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. |
| else | |
| FUNCTION | Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. |
| end case | |
| SUBUNIT | Homodimer. |
| case <OC:Bacillaceae> | |
| DOMAIN | The N-terminal domain has binding sites for ComK and probably for unfolded/aggregated proteins; the C-terminal domain interacts with ClpC. |
| else | |
| DOMAIN | The N-terminal domain probably binds unfolded/aggregated proteins; the C-terminal domain interacts with ClpC. |
| end case | |
| SIMILARITY | Belongs to the MecA family. |
Keywords
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| case <OC:Bacillaceae> | |
| Competence | |
| Sporulation | |
| end case | |
Gene Ontology
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| GO:0030674; Molecular function:protein-macromolecule adaptor activity | |
| case <OCellular component:Bacillaceae> | |
| GO:0045808; Biological process:negative regulation of establishment of competence for transformation | |
| GO:0042174; Biological process:negative regulation of sporulation resulting in formation of a cellular spore | |
| end case | |
Cross-references
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| Pfam | PF05389; MecA; 1; |
| PIRSF | PIRSF029008; MecA; 1; |
Features
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Additional information
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| Size range | 192-253 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |