Annotation rule MF_01132
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General rule information [?]

Accession MF_01132
Dates 2-FEB-2004 (Created)
26-SEP-2014 (Last updated, Version 20)
Name SpxA
Scope Bacteria; Firmicutes
Template O31602 (SPX_BACSU)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SPX
Protein name
RecName: Full=Regulatory protein Spx;
Gene name
spxA

Comments [?]

Function Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Subcellular location Cytoplasm.
Similarity Belongs to the ArsC family. Spx subfamily.

Keywords [?]

case <FT:1>
end case

Gene Ontology [?]

GO:0045892; Biological process: negative regulation of transcription, DNA-templated.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF03960; ArsC; 1;
TIGRFAMs TIGR01617; ArsC_related; 1;

Features [?]

From: SPX_BACSU (O31602)
Key     From     To       Description   Tag   Condition   FTGroup
DISULFID     10     13       Redox-active     C-x-x-C  

Additional information [?]

Size range 128-137 amino acids
Related rules None
Fusion None