HAMAP annotation rule MF_01132
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Accession MF_01132
Dates 2-FEB-2004 (Created)
31-OCT-2011 (Last updated, Version 17)
Name SpxA
Scope Bacteria; Firmicutes
Triggered by



Identifier
SPX
Protein name
RecName: Full=Regulatory protein spx;
Gene name
spxA


FUNCTION Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity).
SUBCELLULAR LOCATION Cytoplasm (By similarity).
SIMILARITY Belongs to the ArsC family. Spx subfamily.


Cytoplasm
case <FT:1>
Disulfide bond
Redox-active center
end case
Transcription
Transcription regulation


GO:0045892; Biological process: negative regulation of transcription, DNA-dependent.
GO:0005737; Cellular component: cytoplasm.


Pfam PF03960; ArsC; 1;
TIGRFAMs TIGR01617; ArsC_related; 1;


From: SPX_BACSU (O31602)
Key     From     To       Description   Tag   Condition   FTGroup
DISULFID     10     13       Redox-active (Potential)     C-x-x-C  


Size range: 128-137 amino acids
Related Rules: None
Template: O31602 (SPX_BACSU)
Fusion: None


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