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HAMAP rule MF_01133

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General rule information [?]

Accession MF_01133
Dates 25-SEP-2003 (Created)
1-JUN-2023 (Last updated, Version 35)
Name RuBisCO_L_type3
Scope(s) Archaea
Template(s) O93627 (RBL_THEKO); Q58632 (RBL_METJA); O28635 (RBL_ARCFU); Q8THG2 (RBL_METAC); [ Recover all ]
Triggered by HAMAP; MF_01133 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RBL
Protein name RecName: Full=Ribulose bisphosphate carboxylase;
                 Short=RuBisCO;
                 EC=4.1.1.39;
Gene name Name=rbcL;

Comments [?]

FUNCTIONCatalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
CATALYTIC ACTIVITY Reaction=2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5- bisphosphate + H2O; Xref=Rhea:RHEA:23124, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57870, ChEBI:CHEBI:58272; EC=4.1.1.39;
CATALYTIC ACTIVITY Reaction=D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+); Xref=Rhea:RHEA:36631, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57870, ChEBI:CHEBI:58033, ChEBI:CHEBI:58272;
case <FTGroup:1>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
end case
SUBUNITHomodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.
MISCELLANEOUSBecause the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
SIMILARITYBelongs to the RuBisCO large chain family. Type III subfamily.

Keywords [?]


Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function:magnesium ion binding
end case
GO:0016984; Molecular function:ribulose-bisphosphate carboxylase activity
GO:0006196; Biological process:AMP catabolic process

Cross-references [?]

Pfam PF00016; RuBisCO_large; 1;
Pfam PF02788; RuBisCO_large_N; 1;
NCBIfam TIGR03326; rubisco_III; 1;

Features [?]

From: RBL_THEKO (O93627)
Key From To Description Tag Condition FTGroup
BINDING 367 369 /ligand="substrate" S-x-G
BINDING 389 392 /ligand="substrate" Q-x-G-G
ACT_SITE 163 163 /note="Proton acceptor" K
ACT_SITE 281 281 /note="Proton acceptor" H
BINDING 189 189 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/note="via carbamate group"
K 1
BINDING 191 191 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D 1
BINDING 192 192 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
E 1
BINDING 165 165 /ligand="substrate" K
BINDING 282 282 /ligand="substrate" R
BINDING 314 314 /ligand="substrate" H
SITE 322 322 /note="Transition state stabilizer" K
MOD_RES 189 189 /note="N6-carboxylysine" K

Additional information [?]

Size range 410-450 amino acids
Related rules MF_01338
MF_01339
Fusion Nter: None Cter: None



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