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HAMAP annotation rule: MF_01136
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General rule information

Accession MF_01136
Dates 20-NOV-2003 (Created)
2-DEC-2011 (Last updated, Version 16)
Data class Protein
Predictors HAMAP; MF_01136; [distribution of match scores in UniProtKB];[seed alignment for MF_01136]
Names CdhE


Propagated annotation

Identifier, protein and gene names
Identifier ACDG
Protein name
RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit gamma;
Short=ACDS complex subunit gamma;
EC=2.1.1.-;
AltName: Full=ACDS complex methyltransferase;
AltName: Full=Corrinoid/iron-sulfur component large subunit;
Gene name cdhE
Comments

case <OC:Methanosarcinaceae>
FUNCTION: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy (By similarity).
end case


case not <OC:Methanosarcinaceae>
FUNCTION: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2) (By similarity).
end case

CATALYTIC ACTIVITY: Cob(I)amide-protein + CH(3)-H(4)SPt + H(+) = CH(3)-cob(III)amide-protein + H(4)SPt.
COFACTOR: Corrinoid (By similarity).
COFACTOR: Binds 1 4Fe-4S cluster (By similarity).

case <OC:Methanosarcinaceae>
PATHWAY: One-carbon metabolism; methanogenesis from acetate.
end case

SUBUNIT: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential).
SIMILARITY: The iron-sulfur centers are similar to those of bacterial-type 4Fe-4S ferredoxins.
Cross-references
Pfam PF03599; CdhD; 1;
PF04060; FeS; 1;
PROSITE PS00198; 4FE4S_FER_1; 1;
Keywords

case <OC:Methanosarcinaceae>
Methanogenesis.
end case

Transferase, Methyltransferase.

case <FTGroup:1>
Metal-binding, Cobalt, Iron, Iron-sulfur, 4Fe-4S.
end case

Gene Ontology

case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case

GO:0008168; Molecular function: methyltransferase activity.

case <OC:Methanosarcinaceae>
GO:0019385; Biological process: methanogenesis, from acetate.
end case

Features
From: ACDG1_METTE (Q50539)
Key     From     To       Description   Condition   FTGroup
METAL     18     18       Iron-sulfur (4Fe-4S) (By similarity)   C   1
METAL     21     21       Iron-sulfur (4Fe-4S) (By similarity)   C   1
METAL     26     26       Iron-sulfur (4Fe-4S) (By similarity)   C   1
METAL     43     43       Iron-sulfur (4Fe-4S) (By similarity)   C   1


Additional information

Size range: 458-488 amino acids
Related UniRules: None
Template: Q50539 (ACDG1_METTE)
Scope: Archaea
Fusion: Nter: None; Cter: None
Duplicate: in METMA, METTE
Plasmid encoded: None

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UniProtKB rule member sequences