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HAMAP annotation rule: MF_01137
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General rule information

Accession MF_01137
Dates 20-NOV-2003 (Created)
31-OCT-2011 (Last updated, Version 15)
Data class Protein
Predictors HAMAP; MF_01137; [distribution of match scores in UniProtKB];[seed alignment for MF_01137]
Names CdhA


Propagated annotation

Identifier, protein and gene names
Identifier ACDA
Protein name
RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit alpha;
Short=ACDS complex subunit alpha;
EC=1.2.99.2;
AltName: Full=ACDS complex carbon monoxide dehydrogenase;
Short=ACDS CODH;
Gene name cdhA
Comments

case <OC:Methanosarcinaceae>
FUNCTION: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy (By similarity).
end case


case not <OC:Methanosarcinaceae>
FUNCTION: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2) (By similarity).
end case

CATALYTIC ACTIVITY: CO + H(2)O + A = CO(2) + AH(2).
COFACTOR: Binds 7 4Fe-4S clusters per heterotetramer (Potential).
COFACTOR: Binds 2 nickel-iron-sulfur clusters per heterotetramer (Potential).

case <OC:Methanosarcinaceae>
PATHWAY: One-carbon metabolism; methanogenesis from acetate.
end case

SUBUNIT: Heterotetramer of two alpha and two epsilon chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential).
DOMAIN: Cluster B is an all-cysteinyl-liganded 4Fe4S cluster; cluster C is a mixed Ni-Fe-S cluster which appears to be the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe4S cluster that bridges the two subunits of the CODH dimer. May contain two additional 4Fe-4S clusters, dubbed E and F, that might reroute electron transfer along different paths.
SIMILARITY: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
Cross-references
Pfam PF00037; Fer4; 2;
PF03063; Prismane; 1;
PRINTS PR00353; 4FE4SFRDOXIN; 1;
TIGRFAMs TIGR00314; CdhA; 1;
PROSITE PS00198; 4FE4S_FER_1; 2;
PS51379; 4FE4S_FER_2; 2; trigger=PRU00711;
Keywords

case <OC:Methanosarcinaceae>
Methanogenesis.
end case

Oxidoreductase.

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5>
Metal-binding, Iron.
end case


case <FTGroup:3>
Nickel.
end case


case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5>
Iron-sulfur.
end case


case <FTGroup:1> or <FTGroup:2> or <FTGroup:4> or <FTGroup:5>
4Fe-4S.
end case

Gene Ontology

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5>
GO:0005506; Molecular function: iron ion binding.
end case


case <FTGroup:3>
GO:0016151; Molecular function: nickel ion binding.
end case

GO:0018492; Molecular function: carbon-monoxide dehydrogenase (acceptor) activity.

case <OC:Methanosarcinaceae>
GO:0019385; Biological process: methanogenesis, from acetate.
end case

Features
From: ACDA_METJA (Q57617)
Key     From     To       Description   Condition   FTGroup
METAL     73     73       Iron-sulfur 1 (4Fe-4S); shared with dimeric partner (By similarity)   C   1
METAL     76     76       Iron-sulfur 1 (4Fe-4S); shared with dimeric partner (By similarity)   C   1
 
METAL     77     77       Iron-sulfur 2 (4Fe-4S) (By similarity)   C   2
METAL     79     79       Iron-sulfur 2 (4Fe-4S) (By similarity)   C   2
METAL     84     84       Iron-sulfur 2 (4Fe-4S) (By similarity)   C   2
METAL     94     94       Iron-sulfur 2 (4Fe-4S) (By similarity)   C   2
 
METAL     251     251       Nickel-iron-sulfur (By similarity)   H   3
METAL     279     279       Nickel-iron-sulfur (By similarity)   C   3
METAL     318     318       Nickel-iron-sulfur (By similarity)   C   3
 
METAL     408     408       Iron-sulfur 3 (4Fe-4S) (Potential)   C   4
METAL     411     411       Iron-sulfur 3 (4Fe-4S) (Potential)   C   4
METAL     414     414       Iron-sulfur 3 (4Fe-4S) (Potential)   C   4
METAL     418     418       Iron-sulfur 3 (4Fe-4S) (Potential)   C   4
 
METAL     446     446       Iron-sulfur 4 (4Fe-4S) (Potential)   C   5
METAL     449     449       Iron-sulfur 4 (4Fe-4S) (Potential)   C   5
METAL     452     452       Iron-sulfur 4 (4Fe-4S) (Potential)   C   5
METAL     456     456       Iron-sulfur 4 (4Fe-4S) (Potential)   C   5
 
METAL     514     514       Nickel-iron-sulfur (By similarity)   C   3
METAL     543     543       Nickel-iron-sulfur (By similarity)   C   3
METAL     578     578       Nickel-iron-sulfur (By similarity)   C   3


Additional information

Size range: 632-807 amino acids
Related UniRules: None
Template: Q08368 (ACDA1_METTE)
Scope: Archaea
Fusion: Nter: None; Cter: None
Duplicate: in ARCFU, METAC, METKA, METMA, METTE
Plasmid encoded: None

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UniProtKB rule member sequences