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HAMAP annotation rule: MF_01138
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General rule information

Accession MF_01138
Dates 20-NOV-2003 (Created)
31-OCT-2011 (Last updated, Version 13)
Data class Protein
Predictors HAMAP; MF_01138; [distribution of match scores in UniProtKB];[seed alignment for MF_01138]
Names CdhC


Propagated annotation

Identifier, protein and gene names
Identifier ACDB
Protein name
RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit beta;
Short=ACDS complex subunit beta;
EC=2.3.1.-;
AltName: Full=ACDS complex acyltransferase;
Gene name cdhC
Comments

case <OC:Methanosarcinaceae>
FUNCTION: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy (By similarity).
end case


case not <OC:Methanosarcinaceae>
FUNCTION: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2) (By similarity).
end case

CATALYTIC ACTIVITY: Acetyl-CoA + [acetyl-CoA decarbonylase/synthase complex beta subunit] = CoA + acetyl-[acetyl-CoA decarbonylase/synthase complex beta subunit].
COFACTOR: Binds 1 nickel-iron-sulfur cluster (By similarity).

case <OC:Methanosarcinaceae>
PATHWAY: One-carbon metabolism; methanogenesis from acetate.
end case

SUBUNIT: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential).
SIMILARITY: Belongs to the CdhC family.
Cross-references
Pfam PF03598; CdhC; 1;
TIGRFAMs TIGR00316; CdhC; 1;
Keywords

case <OC:Methanosarcinaceae>
Methanogenesis.
end case

Transferase, Acyltransferase.

case <FTGroup:1>
Metal-binding, Iron, Nickel, Iron-sulfur.
end case

Gene Ontology
GO:0016407; Molecular function: acetyltransferase activity.

case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
GO:0016151; Molecular function: nickel ion binding.
end case


case <OC:Methanosarcinaceae>
GO:0019385; Biological process: methanogenesis, from acetate.
end case

Features
From: ACDB2_METTE (Q9V2Z4)
Key     From     To       Description   Condition   FTGroup
COMPBIAS     403     416       Glu-rich      
 
METAL     189     189       Nickel-iron-sulfur (Potential)   C   1
METAL     192     192       Nickel-iron-sulfur (Potential)   C   1
METAL     278     278       Nickel-iron-sulfur (Potential)   C   1
METAL     280     280       Nickel-iron-sulfur (Potential)   C   1


Additional information

Size range: 460-524 amino acids
Related UniRules: None
Template: Q9V2Z4 (ACDB2_METTE)
Scope: Archaea
Fusion: Nter: None; Cter: None
Duplicate: in METAC, METMA, METTE
Plasmid encoded: None

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UniProtKB rule member sequences