HAMAP

Accession	MF_01141
Dates	2-MAR-2004 (Created) 26-NOV-2010 (Last updated, Version 15)

Data class

Protein

Predictors

HAMAP; MF_01141; [distribution of match scores in UniProtKB];[seed alignment for MF_01141]

Names

LrgA

Identifier

LRGA

Protein name

RecName: Full=Antiholin-like protein LrgA;

Gene name

lrgA

FUNCTION: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity).

FUNCTION: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity).

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential).

SIMILARITY: Belongs to the CidA/LrgA family. LrgA subfamily.

Pfam	PF03788; LrgA; 1;
General	Transmembrane; -; 4; trigger=Yes;

Cell membrane, Cytolysis, Membrane, Transmembrane, Transmembrane helix.

GO:0019835; Biological process: cytolysis.
GO:0012501; Biological process: programmed cell death.
GO:0005886; Cellular component: plasma membrane.

Size range:	143-152 amino acids
Related UniRules:	None
Template:	P72358 (LRGA_STAA8)
Scope:	Bacteria; Bacillales
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None