Annotation rule MF_01143
Send feedback

General rule information [?]

Accession MF_01143
Dates 4-MAR-2004 (Created)
2-JUL-2010 (Last updated, Version 16)
Name CidA
Scope Bacteria; Bacillales
Template P60647 (CIDA_STAA8)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CIDA
Protein name
RecName: Full=Holin-like protein CidA;
Gene name
cidA

Comments [?]

case <OC:Staphylococcus>
Function Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins. When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential (By similarity).
else
Function Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential (By similarity).
end case
Subcellular location Cell membrane; Multi-pass membrane protein (Potential).
Similarity Belongs to the CidA/LrgA family. CidA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0019835; Biological process: cytolysis.
GO:0012501; Biological process: programmed cell death.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF03788; LrgA; 1;

Computed features [?]

General Transmembrane; -; 4; trigger=yes;

Additional information [?]

Size range 118-131 amino acids
Related rules None
Fusion None