HAMAP

Accession	MF_01143
Dates	4-MAR-2004 (Created) 2-JUL-2010 (Last updated, Version 16)

Data class

Protein

Predictors

HAMAP; MF_01143; [distribution of match scores in UniProtKB];[seed alignment for MF_01143]

Names

CidA

Identifier

CIDA

Protein name

RecName: Full=Holin-like protein CidA;

Gene name

cidA

FUNCTION: Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins. When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential (By similarity).

FUNCTION: Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential (By similarity).

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential).

SIMILARITY: Belongs to the CidA/LrgA family. CidA subfamily.

Pfam	PF03788; LrgA; 1;
General	Transmembrane; -; 4; trigger=Yes;

Cell membrane, Cytolysis, Membrane, Transmembrane, Transmembrane helix.

GO:0019835; Biological process: cytolysis.
GO:0012501; Biological process: programmed cell death.
GO:0005886; Cellular component: plasma membrane.

Size range:	118-131 amino acids
Related UniRules:	None
Template:	P60647 (CIDA_STAA8)
Scope:	Bacteria; Bacillales
Fusion:	Nter: None; Cter: None
Duplicate:	in BACAN, BACCR
Plasmid encoded:	None