HAMAP

Accession	MF_01145
Dates	12-MAR-2004 (Created) 16-MAR-2010 (Last updated, Version 16)

Data class

Protein

Predictors

HAMAP; MF_01145; [distribution of match scores in UniProtKB];[seed alignment for MF_01145]

Names

Foldase_PrsA

Identifier

PRSA

Protein name

RecName: Full=Foldase protein prsA; EC=5.2.1.8; Flags: Precursor;

Gene name

prsA

FUNCTION: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity).

CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).

SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor (Potential).

SIMILARITY: Belongs to the prsA family.

Pfam	PF00639; Rotamase; 1;
PROSITE	PS01096; PPIC_PPIASE_1; 1; PS50198; PPIC_PPIASE_2; 1; trigger=PRU00278; PS51257; PROKAR_LIPOPROTEIN; 1; trigger=PRU00303;

Isomerase, Rotamase, Cell membrane, Membrane.

Lipoprotein, Palmitate.

Signal.

GO:0003755; Molecular function: peptidyl-prolyl cis-trans isomerase activity.
GO:0006457; Biological process: protein folding.

GO:0005886; Cellular component: plasma membrane.

Size range:	248-353 amino acids
Related UniRules:	None
Template:	P24327 (PRSA_BACSU)
Scope:	Bacteria; Firmicutes
Fusion:	Nter: None; Cter: None
Duplicate:	in BACAN, BACCR, LACJO, LACLC, LACPL, LISIN, LISMO, STRP3, STRP8, STRP1
Plasmid encoded:	in LACLC
Comments:	These proteins are typical of Gram-positive bacteria. They share low similarity and may be present in several copies per genome. Some do not possess the PPIase domain but are still active as foldases.