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HAMAP rule MF_01145

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General rule information [?]

Accession MF_01145
Dates 12-MAR-2004 (Created)
13-JAN-2023 (Last updated, Version 21)
Name Foldase_PrsA
Scope(s) Bacteria
Bacillota
Template(s) P24327 (PRSA_BACSU); [ Recover all ]
Triggered by HAMAP; MF_01145 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PRSA
Protein name RecName: Full=Foldase protein PrsA;
                 EC=5.2.1.8;
                 Flags: Precursor;
Gene name Name=prsA;

Comments [?]

FUNCTIONPlays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins.
CATALYTIC ACTIVITY Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8;
case <Feature:PS51257>
SUBCELLULAR LOCATIONCell membrane; Lipid-anchor.
end case
SIMILARITYBelongs to the PrsA family.

Keywords [?]


Gene Ontology [?]

GO:0003755; Molecular function:peptidyl-prolyl cis-trans isomerase activity
GO:0006457; Biological process:protein folding
case <Feature:PS51257>
GO:0005886; Cellular component:plasma membrane
end case

Cross-references [?]

Pfam PF00639; Rotamase; 1;
PROSITE PS01096; PPIC_PPIASE_1; 1;
PROSITE PS50198; PPIC_PPIASE_2; 1;
PROSITE PS51257; PROKAR_LIPOPROTEIN; 1;

Features [?]


Additional information [?]

Size range 248-353 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments These proteins are typical of Gram-positive bacteria. They share low similarity and may be present in several copies per genome. Some do not possess the PPIase domain but are still active as foldases.



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