 |
|
|||||||
| HAMAP annotation rule: MF_01146 |
| Accession | MF_01146 |
| Dates | 25-MAR-2004 (Created) 12-JUL-2010 (Last updated, Version 23) |
| Data class | Protein |
| Predictors | HAMAP; MF_01146; [distribution of match scores in UniProtKB];[seed alignment for MF_01146] |
| Names | Aquaporin_Z |
| Identifier | AQPZ |
| Protein name |
|
| Gene name | aqpZ |
FUNCTION: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity).
SUBUNIT: Homotetramer (By similarity).
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).
end case
case <FT:1> and <FT:2>
DOMAIN: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
end case
SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
| Pfam |
PF00230; MIP; 1; |
| PRINTS |
PR00783; MINTRINSICP; 1; |
| TIGRFAMs |
TIGR00861; MIP; 1; |
| PROSITE |
PS00221; MIP; 1; |
| General |
Transmembrane; -; 6; trigger=Yes; |
case defined <Property:Membrane> and <Property:Membrane=2>
end case
case <FT:1> and <FT:2>
end case
GO:0015250; Molecular function: water channel activity.
GO:0005886; Cellular component: plasma membrane.
GO:0005886; Cellular component: plasma membrane.
| From: AQPZ_ECOLI (P60844) | ||||||||||
| Key | From | To | Description | Condition | FTGroup | |||||
| MOTIF | 63 | 65 | NPA 1 | N-P-A | ||||||
| MOTIF | 186 | 188 | NPA 2 | N-P-A | ||||||
| SITE | 20 | 20 | Involved in tetramerization or stability of the tetramer (By similarity) | C | ||||||
| SITE (Optional) | 43 | 43 | Selectivity filter (By similarity) | F | ||||||
| SITE (Optional) | 174 | 174 | Selectivity filter (By similarity) | H | ||||||
| SITE (Optional) | 183 | 183 | Selectivity filter (By similarity) | T | ||||||
| SITE (Optional) | 189 | 189 | Selectivity filter (By similarity) | R | ||||||
| Size range: | 170-248 amino acids |
| Related UniRules: | None |
| Template: | P60844 (AQPZ_ECOLI) |
| Scope: | Bacteria |
| Fusion: | Nter: None; Cter: None |
| Duplicate: | in AGRT5, RHIME |
| Plasmid encoded: | in AGRT5, RHIME |
View rule in raw text format (no links)