HAMAP

Accession	MF_01151
Dates	7-SEP-2004 (Created) 2-DEC-2011 (Last updated, Version 13)

Data class

Protein

Predictors

HAMAP; MF_01151; [distribution of match scores in UniProtKB];[seed alignment for MF_01151]

Names

GrpE

Identifier

GRPE

Protein name

RecName: Full=Protein grpE; AltName: Full=HSP-70 cofactor;

Gene name

grpE

FUNCTION: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with dnaK and grpE. It is the nucleotide exchange factor for dnaK and may function as a thermosensor. Unfolded proteins bind initially to dnaJ; upon interaction with the dnaJ-bound protein, dnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from dnaK; ATP binding to dnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between dnaJ, dnaK and grpE are required for fully efficient folding (By similarity).

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the grpE family.

Pfam	PF01025; GrpE; 1;
PRINTS	PR00773; GRPEPROTEIN; 1;
PROSITE	PS01071; GRPE; 1;

Cytoplasm, Chaperone, Stress response.

GO:0005737; Cellular component: cytoplasm.

Size range:	157-298 amino acids
Related UniRules:	None
Template:	P09372 (GRPE_ECOLI)
Scope:	Bacteria Archaea; Euryarchaeota
Fusion:	Nter: None; Cter: None
Duplicate:	in BUCAI, BUCAP, BUCBP, STRAW
Plasmid encoded:	None