HAMAP rule MF_01151
General rule information
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| Accession | MF_01151 |
| Dates | 7-SEP-2004 (Created)
8-OCT-2024 (Last updated, Version 17) |
| Name | GrpE |
| Scope(s) |
Bacteria Archaea Methanobacteriati |
| Template(s) | P09372 (GRPE_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01151 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GRPE |
| Protein name | RecName: Full=Protein GrpE; AltName: Full=HSP-70 cofactor; |
| Gene name | Name=grpE; |
Comments
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| FUNCTION | Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the GrpE family. |
Keywords
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Gene Ontology
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| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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Additional information
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| Size range | 157-298 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |