HAMAP

Accession	MF_01158
Dates	17-DEC-2004 (Created) 4-MAR-2011 (Last updated, Version 11)

Data class

Protein

Predictors

HAMAP; MF_01158; [distribution of match scores in UniProtKB];[seed alignment for MF_01158]

Names

Hda

Identifier

HDA

Protein name

RecName: Full=DnaA-homolog protein hda;

Gene name

hda

FUNCTION: Mediates the interactions of DnaA with the beta subunit sliding clamp, promoting hydrolysis of DnaA-bound ATP. It is essential for the control of initiation of DNA replication by inhibiting reinitiation of replication (By similarity).

SIMILARITY: Belongs to the DnaA family. HdA subfamily.

PRINTS

PR00051; DNAA; 1;

DNA replication.

GO:0006260; Biological process: DNA replication.

Size range:	225-248 amino acids
Related UniRules:	None
Template:	P69931 (HDA_ECOLI)
Scope:	Bacteria; Enterobacteriaceae
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	In E.coli this has been shown to be initiated from a CUG start codon (PubMed:18977760), the first CUG start codon found in E.coli, which as it is inefficiently used probably keeps the protein levels low. We have propagated this same start site to other Escherichia and Shigella species but no further.