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HAMAP annotation rule: MF_01162
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General rule information

Accession MF_01162
Dates 11-APR-2005 (Created)
17-AUG-2010 (Last updated, Version 27)
Data class Protein
Predictors HAMAP; MF_01162; [distribution of match scores in UniProtKB];[seed alignment for MF_01162]
Names Aas


Propagated annotation

Identifier, protein and gene names
Identifier AAS
Protein name
RecName: Full=Bifunctional protein aas;
RecName: Full=2-acylglycerophosphoethanolamine acyltransferase;
EC=2.3.1.40;
AltName: Full=2-acyl-GPE acyltransferase;
AltName: Full=Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase;
RecName: Full=Acyl-[acyl-carrier-protein] synthetase;
EC=6.2.1.20;
AltName: Full=Acyl-ACP synthetase;
AltName: Full=Long-chain-fatty-acid--[acyl-carrier-protein] ligase;
Gene name aas
Comments
FUNCTION: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 (By similarity).
CATALYTIC ACTIVITY: Acyl-[acyl-carrier-protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier-protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine.
CATALYTIC ACTIVITY: ATP + an acid + [acyl-carrier-protein] = AMP + diphosphate + acyl-[acyl-carrier-protein].

case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).
end case

SIMILARITY: In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.
SIMILARITY: In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.
Cross-references
Pfam PF01553; Acyltransferase; 1;
PF00501; AMP-binding; 1;
PRINTS PR00154; AMPBINDING; 1;
PROSITE PS00455; AMP_BINDING; 1;
Keywords
Acyltransferase, ATP-binding, Nucleotide-binding.

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane.
end case

Cell membrane, Ligase, Membrane, Multifunctional enzyme, Transferase, Transmembrane, Transmembrane helix.
Gene Ontology
GO:0008779; Molecular function: acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity.
GO:0008922; Molecular function: long-chain fatty acid [acyl-carrier-protein] ligase activity.
GO:0005886; Cellular component: plasma membrane.
Features
From: AAS_ECOLI (P31119)
Key     From     To       Description   Condition   FTGroup
TRANSMEM     258     277       Helical; (Potential)      
TRANSMEM     409     433       Helical; (Potential)      
REGION     15     138       Acyltransferase      
REGION     233     646       AMP-binding      
ACT_SITE     36     36       By similarity   H  


Additional information

Size range: 718-738 amino acids
Related UniRules: None
Template: P31119 (AAS_ECOLI)
Scope: Bacteria; Enterobacteriaceae
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences