HAMAP

Accession	MF_01167
Dates	11-NOV-2005 (Created) 22-JUL-2011 (Last updated, Version 18)

Data class

Protein

Predictors

HAMAP; MF_01167; [distribution of match scores in UniProtKB];[seed alignment for MF_01167]

Names

ArnB_transfer

Identifier

ARNB

Protein name

RecName: Full=UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase; EC=2.6.1.87; AltName: Full=UDP-4-amino-4-deoxy-L-arabinose aminotransferase; AltName: Full=UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase; Short=UDP-Ara4O aminotransferase;

Gene name

arnB

FUNCTION: Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity).

CATALYTIC ACTIVITY: UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + glutamate.

COFACTOR: Pyridoxal phosphate (By similarity).

PATHWAY: Nucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido-beta-L-arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 2/3.

PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the degT/dnrJ/eryC1 family. ArnB subfamily.

Pfam	PF01041; DegT_DnrJ_EryC1; 1;
PIRSF	PIRSF000390; PLP_StrS; 1;

Aminotransferase, Antibiotic resistance, Lipid A biosynthesis, Lipid synthesis, Lipopolysaccharide biosynthesis, Pyridoxal phosphate, Transferase.

GO:0008483; Molecular function: transaminase activity.
GO:0046493; Biological process: lipid A metabolic process.

From: ARNB_ECOLI (P77690)
Key		From		To		Description		Condition		FTGroup
MOD_RES		182		182		N6-(pyridoxal phosphate)lysine (By similarity)		K

Size range:	378-388 amino acids
Related UniRules:	None
Template:	P77690 (ARNB_ECOLI)
Scope:	Bacteria; Gammaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None