HAMAP rule MF_01177
General rule information
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| Accession | MF_01177 |
| Dates | 23-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 22) |
| Name | HTH_type_NsrR |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P0AF63 (NSRR_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01177 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NSRR |
| Protein name | RecName: Full=HTH-type transcriptional repressor NsrR; |
| Gene name | Name=nsrR; |
Comments
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| FUNCTION | Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. |
| case <FTGroup:1> | |
| COFACTOR | Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Note=Binds 1 [2Fe-2S] cluster per subunit.; |
| end case | |
Keywords
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| case <FTGroup:1> | |
| 2Fe-2S | |
| end case | |
| DNA-binding | |
| case <FTGroup:1> | |
| Iron | |
| Iron-sulfur | |
| Metal-binding | |
| end case | |
| Repressor | |
| Transcription | |
| Transcription regulation | |
Gene Ontology
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| GO:0003690; Molecular function:double-stranded DNA binding | |
| case <FTGroup:1> | |
| GO:0005506; Molecular function:iron ion binding | |
| end case | |
| GO:0003700; Molecular function:DNA-binding transcription factor activity | |
| GO:0006355; Biological process:regulation of DNA-templated transcription | |
Cross-references
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| PROSITE | PS01332; HTH_RRF2_1; 1; |
| PROSITE | PS51197; HTH_RRF2_2; 1; |
| Pfam | PF02082; Rrf2; 1; |
| NCBIfam | TIGR00738; Rrf2_super; 1; |
Features
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| From: NSRR_ECOLI (P0AF63) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 91 | 91 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
| BINDING | 96 | 96 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
| BINDING | 102 | 102 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
Additional information
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| Size range | 141-144 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |