HAMAP rule MF_01179
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01179 |
| Accession | MF_01179 |
| Dates | 15-MAY-2008 (Created)
1-JUN-2023 (Last updated, Version 14) |
| Name | SulA |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P0AFZ5 (SULA_ECOLI); Q9HZJ8 (SULA_PSEAE); [ Recover all ] |
| Triggered by |
HAMAP; MF_01179 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SULA |
| Protein name | RecName: Full=Cell division inhibitor SulA; |
| Gene name | Name=sulA; |
Comments
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| FUNCTION | Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. |
| SUBUNIT | Interacts with FtsZ. |
| INDUCTION | By DNA damage, as part of the SOS response. |
| PTM | Is rapidly cleaved and degraded by the Lon protease once DNA damage is repaired. |
| SIMILARITY | Belongs to the SulA family. |
Keywords
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Gene Ontology
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| GO:0051782; Biological process:negative regulation of cell division |
| GO:0006974; Biological process:DNA damage response |
| GO:0009432; Biological process:SOS response |
Cross-references
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Features
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| From: SULA_ECOLI (P0AFZ5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 106 | 112 | /note="FtsZ binding" | A-L-x-[TS]-G-N-Y | ||||||||
| REGION | 162 | 169 | /note="Lon protease binding" | [KR]-I-H-S-x-x-x-H | ||||||||
| SITE | 169 | 169 | /note="Essential for degradation by Lon protease" | H | ||||||||
Additional information
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| Size range | 168-177 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Due to the high divergence of SulA sequences, this family includes only members from the Enterobacterales. There is a 3D-structure available for SulA from Pseudomonas aeruginosa; this protein is not a member of this family though it probably has the same function; the information derived from the structure was included in this rule. It is not clear whether SulA is located in the cytoplasm or is inner-membrane associated. The sulA gene is interrupted by an insertion sequence in Shigella dysenteriae serotype 1 (strain Sd197). |