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| HAMAP annotation rule MF_01180 |
| Accession | MF_01180 |
| Dates | 15-OCT-2008 (Created) 30-MAY-2011 (Last updated, Version 8) |
| Name | FliT |
| Scope | Bacteria; Enterobacteriaceae |
| Triggered by |
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| Protein name |
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| FUNCTION | Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity). |
| SUBUNIT | Homodimer. Interacts with FliD and FlhC (By similarity). |
| SUBCELLULAR LOCATION | Cytoplasm, cytosol (By similarity). |
| SIMILARITY | Belongs to the FliT family. |
GO:0005737; Cellular component: cytoplasm.
GO:0045718; Biological process: negative regulation of flagellum assembly.
GO:0006457; Biological process: protein folding.
GO:0045718; Biological process: negative regulation of flagellum assembly.
GO:0006457; Biological process: protein folding.
| Pfam | PF05400; FliT; 1; |
| From: FLIT_SALTY (P0A1N2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 1 | 50 | Required for homodimerization (By similarity) | |||||||||
| REGION | 60 | 98 | FliD binding (By similarity) | |||||||||
| Size range: | 120-126 amino acids |
| Related Rules: | None |
| Template: | P0A1N2 (FLIT_SALTY) |
| Fusion: | None |