HAMAP

Accession	MF_01180
Dates	15-OCT-2008 (Created) 30-MAY-2011 (Last updated, Version 8)

Data class

Protein

Predictors

HAMAP; MF_01180; [distribution of match scores in UniProtKB];[seed alignment for MF_01180]

Names

FliT

Identifier

FLIT

Protein name

RecName: Full=Flagellar protein FliT;

Gene name

fliT

FUNCTION: Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity).

SUBUNIT: Homodimer. Interacts with FliD and FlhC (By similarity).

SUBCELLULAR LOCATION: Cytoplasm, cytosol (By similarity).

SIMILARITY: Belongs to the FliT family.

Pfam	PF05400; FliT; 1;

Bacterial flagellum biogenesis, Chaperone, Cytoplasm, Repressor, Transcription, Transcription regulation.

GO:0005737; Cellular component: cytoplasm.
GO:0045718; Biological process: negative regulation of flagellum assembly.
GO:0006457; Biological process: protein folding.

From: FLIT_SALTY (P0A1N2)
Key		From		To		Description		Condition		FTGroup
REGION		1		50		Required for homodimerization (By similarity)
REGION		60		98		FliD binding (By similarity)

Size range:	120-126 amino acids
Related UniRules:	None
Template:	P0A1N2 (FLIT_SALTY)
Scope:	Bacteria; Enterobacteriaceae
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None