Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST.
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Annotation rule MF_01184
Send feedback

General rule information [?]

Accession MF_01184
Dates 6-MAY-2008 (Created)
26-SEP-2014 (Last updated, Version 13)
Name XPRTase
Scope Bacteria
Template P42085 (XPT_BACSU)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
XPT
Protein name
RecName: Full=Xanthine phosphoribosyltransferase;
Short=XPRTase;
EC=2.4.2.22;
Gene name
xpt

Comments [?]

Function Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
Catalytic activity XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.
Pathway Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.

Keywords [?]


Gene Ontology [?]

GO:0000310; Molecular function: xanthine phosphoribosyltransferase activity.
GO:0006166; Biological process: purine ribonucleoside salvage.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00103; PUR_PYR_PR_TRANSFER; 1;
Pfam PF00156; Pribosyltran; 1;
TIGRFAMs TIGR01744; XPRTase; 1;

Features [?]

From: XPT_BACSU (P42085)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     128     132       5-phospho-alpha-D-ribose 1-diphosphate binding        
BINDING     20     20       Xanthine; via amide nitrogen and carbonyl oxygen     L  
BINDING     27     27       Xanthine     [NT]  
BINDING     156     156       Xanthine     K  

Additional information [?]

Size range 188-211 amino acids
Related rules None
Fusion None