HAMAP rule MF_01185
General rule information
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| Accession | MF_01185 |
| Dates | 14-DEC-2006 (Created)
19-NOV-2019 (Last updated, Version 23) |
| Name | FliW |
| Scope(s) |
Bacteria |
| Template(s) | O83664 (FLIW_TREPA); P96503 (FLIW_BACSU); Q0P9H9 (FLIW_CAMJE); Q0P9F1 (CSRA_CAMJE); [ Recover all ] |
| Triggered by |
HAMAP; MF_01185 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FLIW |
| Protein name | RecName: Full=Flagellar assembly factor FliW; |
| Gene name | Name=fliW; |
Comments
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| FUNCTION | Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum. |
| SUBUNIT | Interacts with translational regulator CsrA and flagellin(s). |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the FliW family. |
Keywords
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Gene Ontology
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| GO:0044780; Biological process:bacterial-type flagellum assembly |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF02623; FliW; 1; |
Features
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Additional information
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| Size range | 126-175 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The ancestral operon is thought to be Fliw-CsrA, where CsrA is dedicated to controlling flagellar assembly and motility. Rounds of gene loss and re-acquisition in Gammaproteobacteria (which only rarely encode FliW) have lead to CsrA being repurposed for a larger role in translation control. See PubMed:25833324, Vakulskas et al., Microbiol. Mol. Biol. Rev. 79:193-224(2015) for a review. |