HAMAP rule MF_01192
General rule information
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| Accession | MF_01192 |
| Dates | 12-JUL-2007 (Created)
19-NOV-2022 (Last updated, Version 15) |
| Name | Xni |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P38506 (XNI_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01192 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | XNI |
| Protein name | RecName: Full=Flap endonuclease Xni; Short=FEN; EC=3.1.-.-; |
| Gene name | Name=xni; Synonyms=ygdG; |
Comments
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| FUNCTION | Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 Mg(2+) per subunit. Only one magnesium ion has a direct interaction with the protein, the other interactions are indirect.; |
| COFACTOR | Name=K(+); Xref=ChEBI:CHEBI:29103; Note=Binds 1 K(+) per subunit. The potassium ion strongly increases the affinity for DNA.; |
| SIMILARITY | Belongs to the Xni family. |
Keywords
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Gene Ontology
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| GO:0000287; Molecular function:magnesium ion binding |
| GO:0003677; Molecular function:DNA binding |
| GO:0017108; Molecular function:5'-flap endonuclease activity |
| GO:0030955; Molecular function:potassium ion binding |
| GO:0033567; Biological process:DNA replication, Okazaki fragment processing |
Cross-references
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Features
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| From: XNI_ECOLI (P38506) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 184 | 189 | /note="Interaction with DNA" | |||||||||
| BINDING | 104 | 104 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 171 | 171 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103" |
[LIMF] | ||||||||
| BINDING | 172 | 172 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103" |
A | ||||||||
| BINDING | 180 | 180 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103" |
P | ||||||||
| BINDING | 182 | 182 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103" |
[VI] | ||||||||
| BINDING | 185 | 185 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103" |
[IV] | ||||||||
Additional information
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| Size range | 250-290 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |