HAMAP

Accession	MF_01195
Dates	8-APR-2008 (Created) 11-OCT-2011 (Last updated, Version 10)

Data class

Protein

Predictors

HAMAP; MF_01195; [distribution of match scores in UniProtKB];[seed alignment for MF_01195]

Names

NanM

Identifier

NANM

Protein name

RecName: Full=N-acetylneuraminate epimerase; EC=5.1.3.24; AltName: Full=N-acetylneuraminate mutarotase; Short=Neu5Ac mutarotase; AltName: Full=Sialic acid epimerase; Flags: Precursor;

Gene name

nanM

FUNCTION: Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity).

CATALYTIC ACTIVITY: N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate.

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Periplasm (By similarity).

SIMILARITY: Belongs to the nanM family.

SIMILARITY: Contains 7 Kelch repeats.

Pfam	PF01344; Kelch_1; 1;
TIGRFAMs	TIGR03547; Muta_rot_YjhT; 1;
General	Signal; -; 1; trigger=Yes;

Carbohydrate metabolism, Isomerase, Kelch repeat, Periplasm, Repeat, Signal.

GO:0016857; Molecular function: racemase and epimerase activity, acting on carbohydrates and derivatives.
GO:0042597; Cellular component: periplasmic space.

From: NANM_ECOLI (P39371)
Key		From		To		Description		Condition		FTGroup
REPEAT		40		84		Kelch 1
REPEAT		86		137		Kelch 2
REPEAT		139		173		Kelch 3
REPEAT		174		219		Kelch 4
REPEAT		222		265		Kelch 5
REPEAT		287		336		Kelch 6
REPEAT		338		367		Kelch 7
ACT_SITE		228		228		Proton acceptor (Potential)		E

Size range:	368-392 amino acids
Related UniRules:	None
Template:	P39371 (NANM_ECOLI)
Scope:	Bacteria; Proteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in ECOL6
Plasmid encoded:	None