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Annotation rule MF_01201
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General rule information [?]

Accession MF_01201
Dates 6-FEB-2002 (Created)
18-MAY-2015 (Last updated, Version 37)
Name Ala_racemase
Scope Bacteria
Archaea
Templates P10724 (ALR_GEOSE); Q9RER4 (ALR_AQUPY); Q9S5V6 (ALR_BACPS); P10725 (ALR1_BACSU); P0A6B4 (ALR1_ECOLI); P29012 (ALR2_ECOLI); O30746 (ALR2_KLEAE); Q9FCV2 (ALR_LACRE); G2K4Q7 (ALR_LISM4); Q9L888 (ALR_MYCAV); P94967 (ALR_MYCSM); P9WQA9 (ALR_MYCTU); Q9HUN4 (ALR1_PSEAE); Q9HTQ2 (ALR2_PSEAE); P33162 (ALR_PSEFL); Q9RAE7 (ALR2_RHIL3); P0A1A3 (ALR1_SALTY); P06191 (ALR2_SALTY); Q932V0 (ALR1_SHIDY); Q93HP9 (ALR1_SHISO): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ALR
Protein name
RecName: Full=Alanine racemase;
EC=5.1.1.1;

Comments [?]

Function Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Catalytic activity L-alanine = D-alanine.
Cofactor pyridoxal 5'-phosphate
Pathway Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.
Similarity Belongs to the alanine racemase family.

Keywords [?]


Gene Ontology [?]

GO:0008784; Molecular function: alanine racemase activity.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0006522; Biological process: alanine metabolic process.

Cross-references [?]

Pfam PF00842; Ala_racemase_C; 1;
PF01168; Ala_racemase_N; 1;
PRINTS PR00992; ALARACEMASE; 1;
TIGRFAMs TIGR00492; alr; 1;
PROSITE PS00395; ALANINE_RACEMASE; 1;

Features [?]

From: ALR_GEOSE (P10724)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     39     39       Proton acceptor; specific for D-alanine     K  
ACT_SITE     265     265       Proton acceptor; specific for L-alanine     Y  
BINDING (Optional)     136     136       Substrate     R  
BINDING (Optional)     312     312       Substrate; via amide nitrogen     M  
MOD_RES     39     39       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 300-470 amino acids
Related rules None
Fusion None
Comments Annotated as alanine racemase, but could use other substrates in some organisms. In addition, it is not possible to automatically make a distinction between alr and dadX (or dadB) genes, but if these two genes are found in a genome, note that the catabolic alanine racemase dadX (which only exists in several species) is part of the dad operon (i.e. must be close to dadA gene).