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| HAMAP annotation rule: MF_01203 |
| Accession | MF_01203 |
| Dates | 8-FEB-2002 (Created) 13-JUL-2010 (Last updated, Version 30) |
| Data class | Protein |
| Predictors | HAMAP; MF_01203; [distribution of match scores in UniProtKB];[seed alignment for MF_01203] |
| Names | CLC_ClcB |
case <OC:Enterobacteriaceae>
| Identifier | CLCB |
| Protein name |
|
| Gene name | clcB |
else
| Identifier | CLCL |
| Protein name |
|
end case
case <OC:Enterobacteriaceae>
FUNCTION: Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response (By similarity).
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).
end case
SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily.
| Pfam |
PF00654; Voltage_CLC; 1; |
| PRINTS |
PR00762; CLCHANNEL; 1; |
| General |
Transmembrane; -; 9-11; trigger=Yes; |
Transport,
Ion transport,
Ionic channel,
Voltage-gated channel,
Chloride channel,
Chloride,
Membrane.
case defined <Property:Membrane> and <Property:Membrane=2>
end case
GO:0005247; Molecular function: voltage-gated chloride channel activity.
GO:0006821; Biological process: chloride transport.
GO:0005886; Cellular component: plasma membrane.
GO:0006821; Biological process: chloride transport.
GO:0005886; Cellular component: plasma membrane.
| Size range: | 414-461 amino acids |
| Related UniRules: | None |
| Template: | P76175 (CLCB_ECOLI) |
| Scope: | Bacteria |
| Fusion: | Nter: None; Cter: None |
| Duplicate: | None |
| Plasmid encoded: | in RALSO |
| Comments: | In view of recent findings for ClcA in E.coli, ClcB may also be an exchange transporter and not a voltage-gated channel. |
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