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HAMAP annotation rule: MF_01204
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General rule information

Accession MF_01204
Dates 7-MAR-2002 (Created)
2-DEC-2010 (Last updated, Version 24)
Data class Protein
Predictors HAMAP; MF_01204; [distribution of match scores in UniProtKB];[seed alignment for MF_01204]
Names Oxidoreductase_RutE_HadB


Propagated annotation

Identifier, protein and gene names

case <OC:Enterobacteriaceae>
Identifier RUTE
Protein name
RecName: Full=Probable malonic semialdehyde reductase RutE;
EC=1.1.1.298;
Gene name rutE
end case


case not <OC:Enterobacteriaceae>
Identifier Ynnn
Protein name
RecName: Full=Putative NADH dehydrogenase/NAD(P)H nitroreductase ;
EC=1.-.-.-;
end case

Comments

case <OC:Enterobacteriaceae>
FUNCTION: May reduce toxic product malonic semialdehyde to 3-hydroxypropionic acid, which is excreted. (By similarity).
CATALYTIC ACTIVITY: 3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + NADPH.
end case

COFACTOR: FMN (Potential).

case <OC:Escherichia> or <OC:Shigella>
INDUCTION: Up-regulated by the nitrogen regulatory protein C (NtrC also called GlnG) and repressed by RutR (Potential).
end case

SIMILARITY: Belongs to the nitroreductase family. HadB/RutE subfamily.
Cross-references
Pfam PF00881; Nitroreductase; 1;
Keywords
Oxidoreductase, NAD, NADP, Flavoprotein, FMN.
Gene Ontology

case <OC:Enterobacteriaceae>
GO:0035527; Molecular function: 3-hydroxypropionate dehydrogenase (NADP+) activity.
GO:0006212; Biological process: uracil catabolic process.
GO:0019740; Biological process: nitrogen utilization.
end case


case not <OC:Enterobacteriaceae>
GO:0016491; Molecular function: oxidoreductase activity.
GO:0055114; Biological process: oxidation-reduction process.
end case



Additional information

Size range: 195-202 amino acids
Related UniRules: None
Template: P75894 (RUTE_ECOLI)
Scope: Bacteria
Fusion: Nter: None; Cter: None
Duplicate: in STRCO
Plasmid encoded: None
Comments: The rut operon for pyrimidine utilization seems to be absent in salmonellae.

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UniProtKB rule member sequences