Annotation rule MF_01211
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General rule information [?]

Accession MF_01211
Dates 17-JUN-2002 (Created)
27-NOV-2013 (Last updated, Version 38)
Name DHODB_Fe_S_bind
Scope Bacteria
Archaea

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PYRK
case <OC:Bacteria>
Protein name
RecName: Full=Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit;
AltName: Full=Dihydroorotate oxidase B, electron transfer subunit;
end case
case <OC:Archaea>
Protein name
RecName: Full=Probable dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit;
AltName: Full=Dihydroorotate oxidase B, electron transfer subunit;
end case
Gene name
pyrK

Comments [?]

Function Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+) (By similarity).
Cofactor Binds 1 2Fe-2S cluster per subunit (By similarity).
Binds 1 FAD per subunit (By similarity).
Pathway Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD(+) route); step 1/1.
Subunit Heterotetramer of 2 PyrK and 2 PyrD type B subunits (By similarity).
Similarity Belongs to the PyrK family.

Keywords [?]


Gene Ontology [?]

GO:0009055; Molecular function: electron carrier activity.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.
GO:0055114; Biological process: oxidation-reduction process.

Cross-references [?]

Pfam PF10418; DHODB_Fe-S_bind; 1;
PF00970; FAD_binding_6; 1;
PF00175; NAD_binding_1; 1;
PIRSF PIRSF006816; Cyc3_hyd_g; 1;
PRINTS PR00409; PHDIOXRDTASE; 1;
PROSITE PS00197; 2FE2S_FER_1; 0-1;
PS51384; FAD_FR; 1; trigger=PRU00716;

Features [?]

case <OC:Bacteria>
From: PYRK_LACLM (P56968)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     53     56       FAD (By similarity)     R-P-x-S  
NP_BIND (Optional)     70     72       FAD (By similarity)     [LIV]-x-[RQ]  
NP_BIND     79     80       FAD (By similarity)     G-T  
end case
METAL     226     226       Iron-sulfur (2Fe-2S) (By similarity)     C  
METAL     231     231       Iron-sulfur (2Fe-2S) (By similarity)     C  
METAL     234     234       Iron-sulfur (2Fe-2S) (By similarity)     C  
METAL     249     249       Iron-sulfur (2Fe-2S) (By similarity)     C  

Additional information [?]

Size range 232-266 amino acids
Related rules None
Templates P56968 (PYRK_LACLM); P25983 (PYRK_BACSU); P0DH76 (PYRK_ENTFA): [Recover all]
Fusion None
Comments Divergent THEMA and THEP1, annotated as "atypical" since they are quite divergent from the family profile, but can be thought to be PyrK proteins as the gene is adjacent to pyrD.