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HAMAP annotation rule: MF_01219
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General rule information

Accession MF_01219
Dates 28-AUG-2002 (Created)
19-JUL-2011 (Last updated, Version 19)
Data class Protein
Predictors HAMAP; MF_01219; [distribution of match scores in UniProtKB];[seed alignment for MF_01219]
Names PyrR


Propagated annotation

Identifier, protein and gene names
Identifier PYRR
Protein name
RecName: Full=Bifunctional protein pyrR;
RecName: Full=Pyrimidine operon regulatory protein;
RecName: Full=Uracil phosphoribosyltransferase;
Short=UPRTase;
EC=2.4.2.9;
Gene name pyrR
Comments

case <OC:Firmicutes>
FUNCTION: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (By similarity).
end case


case not <OC:Firmicutes>
FUNCTION: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines (By similarity).
end case

FUNCTION: Displays also a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity).
CATALYTIC ACTIVITY: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.

case <OC:Firmicutes>
SUBUNIT: Homodimer and homohexamer; in equilibrium (By similarity).
end case

SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Cross-references
Pfam PF00156; Pribosyltran; 1;
PROSITE PS00103; PUR_PYR_PR_TRANSFER; 1;
Keywords
Transcription.

case <OC:Firmicutes>
Transcription regulation, Transcription termination, RNA-binding.
end case


case not <OC:Firmicutes>
Transcription regulation.
end case

Transferase, Glycosyltransferase.
Gene Ontology

case <OC:Firmicutes>
GO:0003723; Molecular function: RNA binding.
end case

GO:0004845; Molecular function: uracil phosphoribosyltransferase activity.

case not <OC:Firmicutes>
GO:0006355; Biological process: regulation of transcription, DNA-dependent.
end case


case <OC:Firmicutes>
GO:0006353; Biological process: transcription termination, DNA-dependent.
end case

Features
From: PYRR_BACSU (P39765)
Key     From     To       Description   Condition   FTGroup
MOTIF     101     113       PRPP-binding (By similarity)      


Additional information

Size range: 168-193 amino acids
Related UniRules: None
Template: P39765 (PYRR_BACSU); P41007 (PYRR_BACCL); F2MMP6 (PYRR_ENTFO): [Recover all]
Scope: Bacteria
Fusion: Nter: None; Cter: None
Duplicate: in LACPL
Plasmid encoded: None

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UniProtKB rule member sequences