HAMAP

Accession	MF_01227
Dates	20-SEP-2002 (Created) 17-AUG-2010 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_01227; [distribution of match scores in UniProtKB];[seed alignment for MF_01227]

Names

PyrG

Identifier

PYRG

Protein name

RecName: Full=CTP synthase; EC=6.3.4.2; AltName: Full=CTP synthetase; AltName: Full=UTP--ammonia ligase;

Gene name

pyrG

FUNCTION: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity).

CATALYTIC ACTIVITY: ATP + UTP + NH(3) = ADP + phosphate + CTP.

ENZYME REGULATION: Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP (By similarity).

PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.

SUBUNIT: Homotetramer (By similarity).

SIMILARITY: Belongs to the CTP synthase family.

SIMILARITY: Contains 1 glutamine amidotransferase type-1 domain.

Pfam	PF00117; GATase; 1;
TIGRFAMs	TIGR00337; PyrG; 1;
PROSITE	PS51273; GATASE_TYPE_1; 1; trigger=PRU00605;

ATP-binding, Glutamine amidotransferase, Ligase, Nucleotide-binding, Pyrimidine biosynthesis.

GO:0003883; Molecular function: CTP synthase activity.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.

From: PYRG_ECOLI (P0A7E5)
Key		From		To		Description		Condition		FTGroup
REGION		Nter		253		Aminator domain
ACT_SITE		379		379		Nucleophile (By similarity)		C
ACT_SITE		515		515		By similarity		H
ACT_SITE		517		517		By similarity		E

Size range:	524-608 amino acids
Related UniRules:	None
Template:	P0A7E5 (PYRG_ECOLI); P28595 (PYRG_AZOBR); Q59321 (PYRG_CHLTR); O87761 (PYRG_LACLM): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	RPE1 type insert in RICPR and weird insertion in TREPA; sequences not shown in alignment. Divergent UREPA; sequence not included in alignment.